血浆嗜酸性粒细胞计数与冠状动脉扩张之间的关系。
The Relationship Between Plasma Eosinophil Count and Coronary Artery Ectasia.
作者信息
Demir Mehmet, Keceoglu Serdar, Melek Mehmet
机构信息
Bursa Yuksek Ihtisas Education and Research Hospital Cardiology Department, Bursa, Turkey.
出版信息
Cardiol Res. 2013 Oct;4(4-5):159-164. doi: 10.4021/cr280w. Epub 2013 Oct 15.
BACKGROUND
The pathophysiology of coronary artery ectasia (CAE) has not been clearly identified, although multiple abnormalities including arteritis, endothelial dysfunction, and atherothrombosis have been reported. It is known that eosinophils play an important role in inflammation and thrombosis. Also vascular anomalies such as aneurysm have been noted in patients with hypereosinophilic syndromes. We aimed to compare the numbers of eosinophil counts of the patients CAE versus controls.
METHODS
This study included 50 CAE patients (20 male, mean age 60.26 ± 10.6 years) and 30 control person (10 male, mean age 57.86 ± 11.6 years). These participants were performed concurrent routine biochemical tests and neutrophil, lymphocyte, eosinophil count and mean platelet volume (MPV) on whole blood count. These parameters were compared between groups.
RESULTS
Baseline characteristics of the study groups were comparable. CAE patients had a higher MPV value, eosinophil, neutrophil lymphocyte ratio (NLR) than controls (8.5 ± 1 vs 76.2 ± 1.6 fl and 0.198 ± 0.14 vs 0.093 ± 0.058 and 3.0 ± 2.5vs 1.14 ± 0.9; P < 0.001, 0.002 and 0.028 respectively).
CONCLUSION
As a result, our study revealed a relationship between eosinophil count, NLR and MPV in patients with CAE.
背景
尽管已有包括动脉炎、内皮功能障碍和动脉粥样硬化血栓形成在内的多种异常情况被报道，但冠状动脉扩张（CAE）的病理生理学仍未明确。已知嗜酸性粒细胞在炎症和血栓形成中起重要作用。此外，在嗜酸性粒细胞增多综合征患者中也发现了诸如动脉瘤等血管异常情况。我们旨在比较CAE患者与对照组的嗜酸性粒细胞计数。
方法
本研究纳入了50例CAE患者（20例男性，平均年龄60.26±10.6岁）和30例对照者（10例男性，平均年龄57.86±11.6岁）。这些参与者同时进行了常规生化检查以及全血细胞计数中的中性粒细胞、淋巴细胞、嗜酸性粒细胞计数和平均血小板体积（MPV）检测。对这些参数在两组之间进行了比较。
结果
研究组的基线特征具有可比性。CAE患者的MPV值、嗜酸性粒细胞、中性粒细胞淋巴细胞比率（NLR）高于对照组（分别为8.5±1对76.2±1.6 fl，0.198±0.14对0.093±0.058，3.0±2.5对1.14±0.9；P分别<0.001、0.002和0.028）。
结论
因此，我们的研究揭示了CAE患者的嗜酸性粒细胞计数、NLR和MPV之间的关系。
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