苯二氮䓬类药物中毒患者低血糖的发生情况：一项横断面研究。
Occurrence of hypoglycemia in patients with benzodiazepines poisoning: A cross-sectional study.
作者信息
Soroosh Davood, Zakariaei Zakaria, Azadeh Hossein, Tabaripour Rabeeh, Banimostafavi Elham Sadat
机构信息
Department of Internal Medicine, Sabzevar University of Medical Science, Sabzevar, Iran.
Toxicology and Forensic Medicine Division, Orthopedic Research Center, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran.
出版信息
Ann Med Surg (Lond). 2021 Sep 3;69:102772. doi: 10.1016/j.amsu.2021.102772. eCollection 2021 Sep.
BACKGROUND
Benzodiazepine (BZD) poisoning is a common medical condition often accompanied by respiratory arrest, aspiration pneumonitis, and may rarely result in death. Although it is not studied well, hypoglycemia is a real and life-threatening condition that may occur in BZD poisoning. Thus, the present study was shown to determine the prevalence of hypoglycemia among patients with BZD poisoning compared to toxicity with other drugs.
PATIENTS AND METHODS
In this study, patients with drug-induced poisoning referred to Vasei hospital, Sabzevar, eastern Iran, were registered and their blood glucose levels at presentation were collected during 2019.
RESULTS
Overall, 300 poisoned patients were evaluated (17% with BZD poisoning). The prevalence of hypoglycemia was significantly higher in patients with BZD poisoning (11.8% vs. 2.8%, p = 0.004), especially in males (P = 0.016), aged >30 years old (p = 0.006). However, the prevalence of hypoglycemia was higher in patients with GCS<10 (p = 0.005) and in patients referred later than 1 h to a medical center (p = 0.015).
CONCLUSION
Results were show that hypoglycemia is a frequent complication of BZD poisoning and should be considered in the initial evaluation of patients referred to the emergency department with this medical condition.
背景
苯二氮䓬类药物（BZD）中毒是一种常见的医学状况，常伴有呼吸骤停、吸入性肺炎，且极少可能导致死亡。尽管对此研究不足，但低血糖是BZD中毒时可能出现的一种真实且危及生命的状况。因此，本研究旨在确定BZD中毒患者与其他药物中毒患者相比低血糖的发生率。
患者与方法
在本研究中，2019年期间，将转诊至伊朗东部萨卜泽瓦尔的瓦塞医院的药物中毒患者进行登记，并收集其就诊时的血糖水平。
结果
总体上，对300例中毒患者进行了评估（17%为BZD中毒）。BZD中毒患者低血糖的发生率显著更高（11.8%对2.8%，p = 0.004），尤其是男性（P = 0.016）、年龄>30岁者（p = 0.006）。然而，格拉斯哥昏迷评分（GCS）<10分的患者（p = 0.005）以及就诊时间超过1小时才转诊至医疗中心的患者（p = 0.015）低血糖发生率更高。
结论
结果表明低血糖是BZD中毒的常见并发症，对于因这种医学状况转诊至急诊科的患者进行初始评估时应予以考虑。
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