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基于波罗蜜-秋葵黏液的姜黄素黏膜黏附片用于结肠靶向给药的研究

Studies on Jackfruit-Okra Mucilage-Based Curcumin Mucoadhesive Tablet for Colon Targeted Delivery.

作者信息

Kurra Pallavi, Narra Kishore, Orfali Raha, Puttugunta Srinivasa Babu, Khan Shah Alam, Meenakshi Dhanalekshmi Unnikrishnan, Francis Arul Prakash, Asdaq Syed Mohammed Basheeruddin, Imran Mohd

机构信息

Vignan Pharmacy College, Gundur, India.

Department of Pharmaceutical Technology, BIT Campus, Anna University, Tiruchirappalli, India.

出版信息

Front Pharmacol. 2022 Jul 1;13:902207. doi: 10.3389/fphar.2022.902207. eCollection 2022.

DOI:10.3389/fphar.2022.902207
PMID:35846997
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9284007/
Abstract

The present work investigates a blend of jack fruit mucilage (JFM) and okra mucilage (OKM) as promising mucoadhesive carriers for colon-specific delivery of a curcumin (CMN)-loaded mucoadhesive tablet (CMT) formulation. Formulation optimization was performed using central composite design (CCD) to further decipher the effect of varying proportions of the mucoadhesive carriers JFM and OKG on response factors such as drug release (% DR) and mucoadhesive strength (MA). The optimized formulation CMT (F14) demonstrated a favorable 54.35% release of CMN in 12 h with release kinetics resulting from a zero-order anomalous diffusion mechanism and MA of 34.1733 ± 1.26 g. Accelerated stability testing of CMT (F14) confirmed a shelf life of about 4.7 years. drug targeting studies performed using rabbit models in order to observe transit behavior (colon-specific delivery) of the dosage form were assessed by fluoroscopic images of the GI tract. Taking the results together, the results confirm that the combination of JFM and OKM could be exploited as an ideal mucoadhesive carrier for effective delivery of macromolecules to the colon.

摘要

本研究考察了菠萝蜜黏液（JFM）和秋葵黏液（OKM）的混合物，作为一种有前景的黏膜黏附载体，用于结肠特异性递送载有姜黄素（CMN）的黏膜黏附片剂（CMT）制剂。采用中心复合设计（CCD）进行配方优化，以进一步解读黏膜黏附载体JFM和OKG不同比例对药物释放（% DR）和黏膜黏附强度（MA）等响应因子的影响。优化后的制剂CMT（F14）在12小时内显示出良好的54.35%的CMN释放，释放动力学源于零级反常扩散机制，MA为34.1733±1.26 g。CMT（F14）的加速稳定性测试证实其保质期约为4.7年。使用兔模型进行的药物靶向研究，以观察剂型的转运行为（结肠特异性递送），通过胃肠道的荧光图像进行评估。综合这些结果，证实JFM和OKM的组合可作为一种理想的黏膜黏附载体，用于将大分子有效递送至结肠。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/9284007/701a3b12345d/fphar-13-902207-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/9284007/50e0738a8e7a/fphar-13-902207-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/9284007/f80103bf1f6b/fphar-13-902207-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/9284007/f68fd2478c08/fphar-13-902207-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/9284007/4380bea71844/fphar-13-902207-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/9284007/3f59d760274d/fphar-13-902207-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/9284007/67a8f8f082ed/fphar-13-902207-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/9284007/7cf90cdc090d/fphar-13-902207-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/9284007/544b367481cb/fphar-13-902207-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/9284007/701a3b12345d/fphar-13-902207-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/9284007/50e0738a8e7a/fphar-13-902207-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/9284007/f80103bf1f6b/fphar-13-902207-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/9284007/f68fd2478c08/fphar-13-902207-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/9284007/4380bea71844/fphar-13-902207-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/9284007/3f59d760274d/fphar-13-902207-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/9284007/67a8f8f082ed/fphar-13-902207-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/9284007/7cf90cdc090d/fphar-13-902207-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/9284007/544b367481cb/fphar-13-902207-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7a3/9284007/701a3b12345d/fphar-13-902207-g009.jpg

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