Zhou Haiying, Dong Yanzhao, Alhaskawi Ahmad, Lai Jingtian, Wang Zewei, Ezzi Sohaib Hasan Abdullah, Kota Vishnu Goutham, Abdulla Mohamed Hasan Abdulla Hasan, Sun Zhenyu, Lu Hui
Department of Orthopedics, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Zhejiang University School of Medicine, Hangzhou, China.
Front Pharmacol. 2022 Jun 29;13:907629. doi: 10.3389/fphar.2022.907629. eCollection 2022.
The metabolism of bone tumors is extraordinarily complex and involves many signaling pathways and processes, including the tumor necrosis factor (TNF) signaling pathway, which consists of TNF factors and the TNF receptors that belong to the TNF receptor superfamily (TNFRSF). It is appreciated that signaling events and pathways involving TNFRSF components are essential in coordinating the functions of multiple cell types that act as a host defense network against pathogens and malignant cells, the implications of TNFRSF-related signaling pathways on bone tumor metabolism remain to be summarized, which is one of the significant obstacles to the application of TNF-related treatment modalities in the domain of bone oncology. This review will discuss and summarize the anti-tumor properties of important TNFRSF components concerning osteosarcoma, chondrosarcoma, and Ewing sarcoma.
骨肿瘤的代谢极其复杂，涉及许多信号通路和过程，包括肿瘤坏死因子（TNF）信号通路，该通路由TNF因子和属于TNF受体超家族（TNFRSF）的TNF受体组成。人们认识到，涉及TNFRSF成分的信号事件和通路对于协调多种细胞类型的功能至关重要，这些细胞类型构成了抵御病原体和恶性细胞的宿主防御网络，然而，TNFRSF相关信号通路对骨肿瘤代谢的影响仍有待总结，这是TNF相关治疗方式在骨肿瘤学领域应用的重大障碍之一。本综述将讨论并总结重要TNFRSF成分对骨肉瘤、软骨肉瘤和尤因肉瘤的抗肿瘤特性。
