Immunobiology Department, Massachusetts General Hospital, Boston, MA, United States.
Harvard Medical School, Boston, MA, United States.
Front Immunol. 2023 Aug 17;14:1225704. doi: 10.3389/fimmu.2023.1225704. eCollection 2023.
The tumor necrosis factor (TNF) receptor superfamily is a structurally and functionally related group of cell surface receptors that play crucial roles in various cellular processes, including apoptosis, cell survival, and immune regulation. This review paper synthesizes key findings from recent studies, highlighting the importance of clustering in TNF receptor superfamily signaling. We discuss the underlying molecular mechanisms of signaling, the functional consequences of receptor clustering, and potential therapeutic implications of targeting surface structures of receptor complexes.
肿瘤坏死因子（TNF）受体超家族是一组结构和功能相关的细胞表面受体，它们在细胞凋亡、细胞存活和免疫调节等各种细胞过程中发挥着关键作用。这篇综述文章综合了最近研究的关键发现，强调了 TNF 受体超家族信号转导中聚集的重要性。我们讨论了信号转导的潜在分子机制、受体聚集的功能后果以及靶向受体复合物表面结构的潜在治疗意义。
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