Xin Hong
Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
J Cell Immunol. 2022;4(1):29-33. doi: 10.33696/immunology.4.130.
The study " provides the first insight into the critical role of C5 in the host antimicrobial defense to . This study also establishes an inbred A/J mouse model of systemic infection without drug-induced immunosuppression. has become the first fungal pathogen causing global public health threat due to its multidrug resistance (MDR) and persistence in hospital and nursing home settings. Currently, as compared to , very limited animal models are available to study the progression of non (NAC) species including . We have successfully established immunosuppressed C57BL/6, BALB/c and A/J murine models of disseminated candidiasis caused by five clinically significant species: . and . Here we also report updated progress of some important mouse models for infection in the field. These valuable mouse models can be used for the assessment of antifungal drugs, evaluation of potential vaccines and monoclonal antibodies (mAbs) to protect before and after candidiasis, and comparison of pathogenicity of different species.
该研究“首次深入了解了C5在宿主抗微生物防御中的关键作用。本研究还建立了一种无药物诱导免疫抑制的系统性感染近交A/J小鼠模型。由于其多重耐药性（MDR）以及在医院和疗养院环境中的持续存在，已成为首个对全球公共卫生构成威胁的真菌病原体。目前，与……相比，可用于研究包括……在内的非（NAC）物种进展的动物模型非常有限。我们已成功建立了由五种具有临床意义的……物种引起的播散性念珠菌病的免疫抑制C57BL/6、BALB/c和A/J小鼠模型：……和……。在此，我们还报告了该领域一些重要的感染小鼠模型的最新进展。这些有价值的小鼠模型可用于评估抗真菌药物、评估潜在疫苗和单克隆抗体（mAb）以在念珠菌病前后提供保护，以及比较不同……物种的致病性。
