Lindgren B R, Brundin A, Andersson R G
J Allergy Clin Immunol. 1987 Jun;79(6):941-6. doi: 10.1016/0091-6749(87)90244-2.
We investigated the possibility that clonidine, an alpha 2-adrenoceptor agonist, can reduce the wheal-and-flare reactions induced by intradermal injections of allergen in patients with extrinsic asthma. Ten adult subjects with asthma with positive skin tests to one or several pollens were selected. They received, in random order and double-blind manner, clonidine (two doses, each 75 micrograms) or placebo for 3 days, and then, after a 1-week washout period, they crossed over to the other treatment for 3 days. Treatment with clonidine reduced the area of wheal-and-flare reaction induced by allergen without significantly changing the blood pressure or the plasma cortisol level. There was a drop in the histamine content of leukocytes and in the number of eosinophils in peripheral blood after allergen challenge during the placebo treatment, whereas clonidine prevented these changes. The results suggest that treatment with clonidine can reduce the inflammatory reactions induced by allergens in subjects with extrinsic asthma.
我们研究了α2肾上腺素能受体激动剂可乐定是否能够减轻外源性哮喘患者皮内注射变应原所诱发的风团及潮红反应。选取了10名对一种或几种花粉皮肤试验呈阳性的成年哮喘患者。他们以随机顺序和双盲方式接受可乐定（两剂，每剂75微克）或安慰剂治疗3天，然后经过1周的洗脱期后，交叉接受另一种治疗3天。可乐定治疗可减少变应原诱发的风团及潮红反应面积，而血压或血浆皮质醇水平无显著变化。在安慰剂治疗期间变应原激发后，白细胞组胺含量及外周血嗜酸性粒细胞数量下降，而可乐定可防止这些变化。结果表明，可乐定治疗可减轻外源性哮喘患者变应原诱发的炎症反应。
