Fox J L
Surg Neurol. 1979 May;11(5):363-8.
The effects of topically applied hemoglobin, methemoglobin, hemin, ferrous chloride (FeCl2) and ferric chloride (FeCl3) were investigated by observation through the operating microscope to determine their effect on the normal and spastic canine basilar artery. Following transclival exposure, the artery was made spastic by puncture or topical barium chloride. No consistent changes in arterial diameter were seen with topical hemoglobin, methemoglobin, or hemin. The buffered ferrous ion (Fe++) caused marked vasodilation at concentrations of 10 microgram/ml. The buffered ferric ion (Fe++) caused mild vasoconstriction at similar concentrations. The possible role of iron (a component of hemoglobin) in vasospasm following subarachnoid hemorrhage and subsequent hemoglobin degradation is discussed.
通过手术显微镜观察，研究了局部应用血红蛋白、高铁血红蛋白、氯高铁血红素、氯化亚铁（FeCl2）和氯化铁（FeCl3）对正常和痉挛性犬基底动脉的影响，以确定它们的作用。经斜坡暴露后，通过穿刺或局部应用氯化钡使动脉痉挛。局部应用血红蛋白、高铁血红蛋白或氯高铁血红素时，未观察到动脉直径有一致变化。缓冲的亚铁离子（Fe++）在浓度为10微克/毫升时引起明显的血管舒张。缓冲的铁离子（Fe++）在类似浓度下引起轻度血管收缩。讨论了铁（血红蛋白的一种成分）在蛛网膜下腔出血后血管痉挛及随后血红蛋白降解中的可能作用。
