Leitão Mariana, Saúde Alexandra, Bouça-Machado Raquel, Ferreira Joaquim J
CNS - Campus Neurológico, Torres Vedras, Portugal.
Instituto de Medicina Molecular João Lobo Antunes, Lisbon, Portugal.
J Alzheimers Dis. 2022;89(1):13-24. doi: 10.3233/JAD-220151.
In addition to cognitive changes, motor impairments have been observed in patients with dementia and are present early in the disease, even at the preclinical stage. Although it is difficult to assess motor function in this population, it is critical for monitoring disease progression and determining the efficacy of therapeutic interventions. However, the best measurement tools for assessing motor function in dementia patients have yet to be determined.
We aimed to summarize and critically evaluate the measurement tools used to assess motor function indementia.
A systematic review was conducted using the databases CENTRAL, MEDLINE, Embase, and PEDro from their inception to June 2021 to identify all experimental studies conducted in patients with dementia and that included an assessment of motor function. Two reviewers independently screened citations, extracted data, and assessed clinimetric properties.
We included 200 studies that assess motor function in dementia patients. Motor function was assessed using a total of 84 different measurement tools. Only nine (12%) were used in over ten studies. The Timed-Up-and-Go test, 6MWT, Berg Balance Scale, and the Short Physical Performance Battery are all suggested.
Currently, a wide variety of measurement instruments are used to assess motor performance in people with dementia, most instruments were not designed for this population and have not been validated for this use. We propose the development of an assessment protocol tailored to the different disease stages. We also recommend that future research continues to develop technological devices that can assist with this task.
除认知变化外，痴呆患者还存在运动障碍，且在疾病早期甚至临床前阶段就已出现。尽管评估该人群的运动功能较为困难，但对于监测疾病进展和确定治疗干预的疗效至关重要。然而，评估痴呆患者运动功能的最佳测量工具尚未确定。
我们旨在总结并严格评估用于评估痴呆患者运动功能的测量工具。
使用CENTRAL、MEDLINE、Embase和PEDro数据库进行系统综述，检索从建库至2021年6月期间所有针对痴呆患者开展的、包括运动功能评估的实验研究。两名评审员独立筛选文献、提取数据并评估测量特性。
我们纳入了200项评估痴呆患者运动功能的研究。共使用了84种不同的测量工具来评估运动功能。只有9种（12%）在超过10项研究中被使用。推荐使用定时起立行走测试、6分钟步行试验、伯格平衡量表和简短体能测试电池。
目前，有各种各样的测量工具用于评估痴呆患者的运动表现，大多数工具并非为此人群设计，也未针对此用途进行验证。我们建议制定针对不同疾病阶段的评估方案。我们还建议未来的研究继续开发有助于完成这项任务的技术设备。
