一种来自内生真菌的新型二酮哌嗪类生物碱。
A new diketopiperazine-type alkaloid from the endophytic fungus .
作者信息
Yao Si, Zhang Runge, Wang Jianping, Gu Lianghu, Hu Zhengxi, Zhang Yonghui
机构信息
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
出版信息
Nat Prod Res. 2023 Oct-Nov;37(21):3716-3721. doi: 10.1080/14786419.2022.2099391. Epub 2022 Jul 18.
A chemical investigation on an endophytic fungus isolated from the medicinal plant Willd. (Plantaginaceae) afforded one new diketopiperazine-type alkaloid, namely penicimine A (), as well as two known congeners ( and ). Their structures were elucidated by widespread spectroscopic data, and the absolute configurations of and were further confirmed by single-crystal X-ray diffraction analyses. Compound represented the first example of benzyl-containing diketopiperazine-type alkaloid bearing a methyl group attached at C-15 position. Compound showed anti-inflammatory activity against LPS-induced nitric oxide (NO) production in RAW264.7 mouse macrophages with an IC value of 25.65 μM.
对从药用植物大车前（车前科）中分离出的一种内生真菌进行化学研究，得到了一种新的二酮哌嗪型生物碱，即青霉胺A（），以及两种已知的同系物（和）。通过广泛的光谱数据阐明了它们的结构，并通过单晶X射线衍射分析进一步确定了和的绝对构型。化合物代表了在C-15位带有甲基的含苄基二酮哌嗪型生物碱的首个实例。化合物对RAW264.7小鼠巨噬细胞中脂多糖诱导的一氧化氮（NO）产生具有抗炎活性，IC值为25.65μM。
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