Robuschi G, Montermini M, Alboni A, Borciani E, Cersosimo G, Negrotti L, Gnudi A, Safran M, Braverman L E, Roti E
J Endocrinol Invest. 1987 Apr;10(2):183-6. doi: 10.1007/BF03347188.
In the present study, we have evaluated thyroid function in neonates at delivery and in their mothers who used vaginal povidone-iodine (PVP-I) during the last trimester of pregnancy. Newborns and their mothers without a history of iodine exposure, admitted to the same department and residing in the same geographical area served as controls. Maternal serum thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and thyrotropin (TSH) concentrations at delivery were not significantly different between the two groups of pregnant women. Cord blood thyroid hormone concentrations in the newborns of iodine exposed mothers were not significantly different from those in control newborns. In contrast, cord blood TSH concentrations in the neonates of mothers exposed to PVP-I during the last trimester of pregnancy were significantly higher than values in control neonates (p less than 0.05). These data confirm that the fetal thyroid gland, even in the last trimester of pregnancy, does not adapt completely to the inhibitory action of iodine on thyroid hormone synthesis and/or release.
在本研究中，我们评估了分娩时新生儿及其在妊娠晚期使用阴道聚维酮碘（PVP-I）的母亲的甲状腺功能。无碘暴露史、入住同一科室且居住在同一地理区域的新生儿及其母亲作为对照。两组孕妇分娩时的母体血清甲状腺素（T4）、三碘甲状腺原氨酸（T3）、反三碘甲状腺原氨酸（rT3）和促甲状腺激素（TSH）浓度无显著差异。碘暴露母亲的新生儿脐带血甲状腺激素浓度与对照新生儿无显著差异。相比之下，妊娠晚期暴露于PVP-I的母亲所生新生儿的脐带血TSH浓度显著高于对照新生儿（p<0.05）。这些数据证实，即使在妊娠晚期，胎儿甲状腺也不能完全适应碘对甲状腺激素合成和/或释放的抑制作用。
