Novaes Júnior M, Biancalana M M, Garcia S A, Rassi I, Romaldini J H
Department of Endocrinology, Hospital Servidor Pubblico, IAMSPE, Sao Paulo, Brasil.
J Endocrinol Invest. 1994 Nov;17(10):805-8. doi: 10.1007/BF03347781.
The thyroid function in full term newborn infants of 30 pregnant women given topical germicide providine-iodine (PVPI) during delivery was evaluated. For comparison 12 full term newborn infants of pregnant women using clorhexidine hydrochloride as germicide in selective cesarean section were designed as control. The two pregnant groups had similar median age (27.5 yr in PVPI group, range: 19-42 yr and 28.5 yr in control group, 19-40 yr) and gestational age (39 weeks, 38-42 weeks and 39.5 weeks, 38-42 weeks). Birth weight (3365 g, 2500-3860 g and 3265 g, 2850-4000 g) and the apgar score (9, 9-10 and 9, 8-10) of newborn were similar in both groups. Umbilical cord blood samples were taken after immediate clamping and serum total T3, total T4, free T4 and TSH concentrations were assayed by an immunofluorimetric method. T3, T4 and free T4 concentrations in the cord blood were not different in PVPI newborn infants (median values: 0.92 nmol/L, 135 nmol/L, and 15.9 pmol/L), in comparison to control newborns (0.97 mmol/L, 140.9 nmol/L and 17.3 pmol/L). In contrast, cord blood TSH concentration in newborn infants of PVPI pregnant women (median value: 6.47 mIU/L) was significantly higher (p < 0.01) than in control newborn infants (4.8 mIU/L). In PVPI exposed group 14 out of 30 newborn infants had TSH concentration above the upper value (6.7 mIU/L) observed in the control groups (X2 = 8.4, p < 0.01). These data suggest that fetal thyroid is susceptible even to acute iodine overload and support the recommendation that PVPI should be avoided during pregnancy.
对30名在分娩期间局部使用杀菌剂聚维酮碘（PVPI）的孕妇所产足月新生儿的甲状腺功能进行了评估。作为对照，设计了12名在选择性剖宫产中使用盐酸氯己定作为杀菌剂的孕妇所产足月新生儿。两组孕妇的年龄中位数相似（PVPI组为27.5岁，范围：19 - 42岁；对照组为28.5岁，19 - 40岁），孕周也相似（PVPI组为39周，38 - 42周；对照组为39.5周，38 - 42周）。两组新生儿的出生体重（PVPI组为3365克，2500 - 3860克；对照组为3265克，2850 - 4000克）和阿氏评分（PVPI组为9分，9 - 10分；对照组为9分，8 - 10分）相似。脐带立即夹紧后采集血样，采用免疫荧光法测定血清总T3、总T4、游离T4和TSH浓度。与对照新生儿（中位数分别为0.97 mmol/L、140.9 nmol/L和17.3 pmol/L）相比，PVPI新生儿脐带血中的T3、T_{4}和游离T_{4}浓度无差异（中位数分别为0.92 nmol/L、135 nmol/L和15.
