通过芳炔插入/螺环化策略获得螺吲哚内酰胺/内酰胺。
Access to Spiroindanolactones/lactams through an Aryne Insertion/Spirocyclization Strategy.
机构信息
Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad 500 007, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
出版信息
Org Lett. 2022 Jul 29;24(29):5372-5375. doi: 10.1021/acs.orglett.2c02046. Epub 2022 Jul 17.
PMID:35848577
Abstract
An efficient and metal-free strategy for the synthesis of spiro-fused indanolactones/lactams has been developed for the reaction of arynes with α-chloroacetyl lactones/lactams. This strategy provides access to spiroindanone derivatives via aryne insertion/spirocyclization.
摘要
发展了一种高效、无金属的策略，用于芳炔与α-氯乙酰基内酰胺/内脂的反应，合成螺环稠合的吲哚烷内脂/内酰胺。该策略通过芳炔插入/螺环化，为合成螺[吲哚酮]衍生物提供了途径。
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