Department of Neurology, Government Medical College, Kozhikode, Kerala, India.
J Postgrad Med. 2022 Jul-Sep;68(3):168-169. doi: 10.4103/jpgm.jpgm_1059_21.
Levetiracetam is a new generation antiseizure medication which binds to synaptic vesicle protein SV2A and inhibits the release of neurotransmitters. Gingival hyperplasia is a common side effect of conventional antiseizure medications like phenytoin, but very rare with the newer ones. A 14-year-old boy was started on levetiracetam 250 mg twice daily after a generalized seizure. Five days later he presented with gingival swelling and painful oral aphthae, without lymphadenopathy or systemic symptoms. Blood investigations were normal. After one-month of stopping the drug, the lesions cleared. This case highlights the importance of maintaining good oral hygiene and periodic dental review in patients on antiseizure medications.
左乙拉西坦是一种新型抗癫痫药物，它与突触囊泡蛋白 SV2A 结合，抑制神经递质的释放。牙龈增生是苯妥英等传统抗癫痫药物的常见副作用，但在新型药物中非常罕见。一名 14 岁男孩在全身性癫痫发作后开始每天服用两次 250 毫克左乙拉西坦。五天后，他出现牙龈肿胀和疼痛性口腔溃疡，无淋巴结病或全身症状。血液检查正常。停药一个月后，病变消退。本病例强调了在服用抗癫痫药物的患者中保持良好的口腔卫生和定期牙科检查的重要性。
