Uegami Mami, Ito Hiroaki, Shiohama Tadashi
Department of Pediatrics, Kameda Medical Center, 929 Higashi-cho, Kamogawa-shi 296-8602, Chiba, Japan.
Department of Pediatrics, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba-shi 260-8670, Chiba, Japan.
Diagnostics (Basel). 2025 Jan 17;15(2):205. doi: 10.3390/diagnostics15020205.
Drug-induced gingival overgrowth is associated with various systemic diseases, including epilepsy. Among antiepileptic medications, phenytoin is commonly reported to cause this condition. In contrast, sodium valproate (VPA), another widely used antiepileptic drug, rarely induces gingival overgrowth. This difference in side effects highlights the variability in drug-induced oral complications among different antiepileptic medications. This case study presents a patient who developed significant gingival overgrowth after using VPA for over 10 years. The study aims to identify VPA as the causative agent and observe changes during long-term administration and after dose reduction. Our findings demonstrate that even long-standing gingival overgrowth can improve rapidly following discontinuation of the causative medication, providing valuable insights for managing similar cases in the future.
药物性牙龈增生与包括癫痫在内的多种全身性疾病有关。在抗癫痫药物中，苯妥英钠常被报道会引发这种情况。相比之下，另一种广泛使用的抗癫痫药物丙戊酸钠（VPA）很少引起牙龈增生。这种副作用的差异凸显了不同抗癫痫药物所致口腔并发症的变异性。本病例研究介绍了一名患者，其在使用VPA超过10年后出现了明显的牙龈增生。该研究旨在确定VPA为致病因素，并观察长期用药及减药过程中的变化。我们的研究结果表明，即使是长期存在的牙龈增生，在停用致病药物后也可迅速改善，为未来处理类似病例提供了有价值的见解。
