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药物性牙龈增生

Medically induced gingival hyperplasia.

作者信息

Meraw S J, Sheridan P J

机构信息

Department of Dental Specialties, Mayo Clinic Rochester, MN 55905, USA.

出版信息

Mayo Clin Proc. 1998 Dec;73(12):1196-9. doi: 10.4065/73.12.1196.

DOI:10.4065/73.12.1196
PMID:9868421
Abstract

Gingival hyperplasia or gingival overgrowth is a common occurrence in patients taking phenytoin, cyclosporine, or calcium channel blockers. Speech, mastication, tooth eruption, and aesthetics may be altered. Controlling the inflammatory component through an appropriate oral hygiene program may benefit the patient by limiting the severity of the gingival overgrowth. In patients in whom gingival overgrowth is present or may be anticipated, recognition of this condition and referral to a general dentist or periodontist are appropriate steps to management. The physician's awareness of the potential for development of overgrowth and the dental practitioner's role in attempting to prevent or minimize this problem are important aspects. In this article, we discuss the medications associated with gingival hyperplasia and describe appropriate recommendations.

摘要

牙龈增生或牙龈过度生长在服用苯妥英钠、环孢素或钙通道阻滞剂的患者中很常见。言语、咀嚼、牙齿萌出和美观可能会受到影响。通过适当的口腔卫生计划控制炎症成分,可能会通过限制牙龈过度生长的严重程度而使患者受益。对于存在或可能出现牙龈过度生长的患者,认识到这种情况并转诊至普通牙医或牙周病医生是合适的管理步骤。医生对过度生长可能性的认识以及牙科从业者在试图预防或最小化此问题方面的作用是重要的方面。在本文中,我们讨论与牙龈增生相关的药物并描述适当的建议。

相似文献

1
Medically induced gingival hyperplasia.药物性牙龈增生
Mayo Clin Proc. 1998 Dec;73(12):1196-9. doi: 10.4065/73.12.1196.
2
Drug-induced gingival overgrowth.药物性牙龈增生
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Drug-induced gingival hyperplasia and its management--a literature review.药物性牙龈增生及其治疗——文献综述
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Prevention and treatment considerations in patients with drug-induced gingival enlargement.药物性牙龈增生患者的防治要点
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Gingival enlargement induced by drugs.药物性牙龈增生
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Case report. Use of an argon laser to treat drug-induced gingival overgrowth.病例报告。使用氩激光治疗药物性牙龈增生。
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[An increase in gingival volume induced by drugs (phenytoin, cyclosporine and calcium antagonists). A review of the literature].[药物(苯妥英钠、环孢素和钙拮抗剂)引起的牙龈体积增大。文献综述]
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Drug-induced gingival hyperplasia in transplant recipients.移植受者的药物性牙龈增生
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J Periodontol. 1996 May;67(5):463-71. doi: 10.1902/jop.1996.67.5.463.

引用本文的文献

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Calcium Channel Blockers- Induced Iatrogenic Gingival Hyperplasia: Case Series.钙通道阻滞剂所致医源性牙龈增生:病例系列
J Pharm Bioallied Sci. 2023 Jul;15(Suppl 1):S821-S824. doi: 10.4103/jpbs.jpbs_634_22. Epub 2023 Jul 5.
2
Drug-Induced Gingival Hyperplasia in a Hypertensive Patient: A Case Report.高血压患者药物性牙龈增生:一例报告
Cureus. 2023 Feb 2;15(2):e34558. doi: 10.7759/cureus.34558. eCollection 2023 Feb.
3
Levetiracetam-induced gingival hyperplasia.左乙拉西坦致牙龈增生。
J Postgrad Med. 2022 Jul-Sep;68(3):168-169. doi: 10.4103/jpgm.jpgm_1059_21.
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Drug-induced gingival hyperplasia: An in vitro study using amlodipine and human gingival fibroblasts.药物性牙龈增生:使用氨氯地平和人牙龈成纤维细胞的体外研究。
Int J Immunopathol Pharmacol. 2019 Jan-Dec;33:2058738419827746. doi: 10.1177/2058738419827746.
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Molecular Aspects of Drug-Induced Gingival Overgrowth: An In Vitro Study on Amlodipine and Gingival Fibroblasts.药物性牙龈过度增生的分子机制:氨氯地平与牙龈成纤维细胞的体外研究。
Int J Mol Sci. 2019 Apr 25;20(8):2047. doi: 10.3390/ijms20082047.
6
Antioxidants and NOX1/NOX4 inhibition blocks TGFβ1-induced CCN2 and α-SMA expression in dermal and gingival fibroblasts.抗氧化剂和NOX1/NOX4抑制可阻断转化生长因子β1诱导的真皮和牙龈成纤维细胞中CCN2和α-平滑肌肌动蛋白的表达。
PLoS One. 2017 Oct 19;12(10):e0186740. doi: 10.1371/journal.pone.0186740. eCollection 2017.
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A Rare Case of Digoxin Associated Gingival Overgrowth.地高辛相关性牙龈增生1例罕见病例
J Clin Diagn Res. 2017 Apr;11(4):ZD30-ZD32. doi: 10.7860/JCDR/2017/25858.9729. Epub 2017 Apr 1.
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Amlodipine-induced Gingival Hyperplasia - A Case Report and Review.氨氯地平所致牙龈增生——病例报告及文献复习
West Indian Med J. 2015 Jun;64(3):279-82. doi: 10.7727/wimj.2014.089. Epub 2015 Apr 14.
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Severe gingival enlargement with coexisting erosive lichen planus in severe chronic periodontitis patient.重度慢性牙周炎患者出现严重牙龈肿大并伴有糜烂性扁平苔藓。
Case Rep Dent. 2015;2015:538538. doi: 10.1155/2015/538538. Epub 2015 Mar 9.
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Combined treatment for a combined enlargement.联合治疗以应对联合性肿大。
J Indian Soc Periodontol. 2014 Jul;18(4):516-9. doi: 10.4103/0972-124X.138747.