Neurosurgery Center, Department of Functional Neurosurgery, The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Eur J Neurosci. 2022 Sep;56(6):4889-4900. doi: 10.1111/ejn.15774. Epub 2022 Jul 22.
Most studies on electrophysiology have not separated aperiodic activity from the spectra but have rather evaluated a combined periodic oscillatory component and the aperiodic component. As the understanding of aperiodic activity gradually deepens, its potential physiological significance has acquired increased appreciation. Herein, we investigated the two components in scalp electroencephalogram in 16 healthy controls and 15 patients with Parkinson's disease (PD); the results revealed that aperiodic parameters were approximately symmetrically distributed in topography in patients with PD and were significantly modulated by dopaminergic medication in channels C4, C3, CP5 and FC5. In sum, our findings might provide indicators for evaluating treatment response in PD and highlight the importance of re-evaluating the neuronal power spectra parameterization.
大多数关于电生理学的研究并没有将无节律活动与频谱分开，而是评估了周期性振荡成分和无节律成分的综合。随着对无节律活动的理解逐渐深入，其潜在的生理意义越来越受到重视。在此，我们对 16 名健康对照者和 15 名帕金森病（PD）患者的头皮脑电图的这两个成分进行了研究；结果表明，无节律参数在 PD 患者的地形图上大致呈对称分布，并在 C4、C3、CP5 和 FC5 通道中被多巴胺能药物显著调节。总之，我们的研究结果可能为评估 PD 的治疗反应提供指标，并强调重新评估神经元功率谱参数化的重要性。
