Shao Ting, Li Hua, Zhang Jiafan, Wang Huifeng, Liu Sai, Long Keli
From the Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, School of Ophthalmology, Shandong First Medical University, Qingdao, Shandong, China.
J Cataract Refract Surg. 2022 Dec 1;48(12):1413-1418. doi: 10.1097/j.jcrs.0000000000001012.
To compare the clinical outcomes, mainly including contrast sensitivity and high-order aberrations (HOAs), between wavefront-optimized (WFO) and corneal wavefront-guided (CWFG) transepithelial photorefractive keratectomy (transPRK) for preoperative HOAs >0.35 μm.
Qingdao Eye Hospital of Shandong First Medical University, Qingdao, Shandong, China.
Prospective randomized controlled study.
71 patients with preoperative total ocular and corneal aberrations >0.35 μm who underwent transPRK for the treatment of myopia and myopic astigmatism were randomly divided into the aberration optimization mode group (WFO group; 36 eyes) and the corneal wavefront-guided mode group (CWFG group; 35 eyes). Preoperative and postoperative visual outcome, refraction, contrast sensitivity, and HOAs were compared.
71 patients (71 eyes) who underwent transPRK were selected. The CWFG group had significantly lower total HOAs and coma values in the corneal aberration compared with the WFO group at 3 ( P = .009; P < .001) and 6 months postoperatively ( P = .006; P < .001). In addition, the CWFG group had significantly lower total HOAs and coma values in the whole-eye aberration compared with the WFO group at 3 ( P = .044; P = .004) and 6 months postoperatively ( P = .026; P = .001). The CWFG group had significantly better improvement in contrast sensitivity than the WFO group at spatial frequencies of 3 cycles per degree (cpd), 6 cpd, 12 cpd, and 18 cpd ( P = .005, P = .007, P = .001, and P < .001, respectively).
CWFG transPRK is associated with better visual and refractive outcomes and less HOAs than WFO transPRK in eyes with preoperative aberrations >0.35 μm.
比较波前优化（WFO）和角膜波前引导（CWFG）经上皮准分子激光角膜切削术（transPRK）治疗术前高阶像差（HOAs）>0.35μm时的临床结果，主要包括对比敏感度和高阶像差。
中国山东青岛山东第一医科大学附属青岛眼科医院。
前瞻性随机对照研究。
71例术前全眼和角膜像差>0.35μm、接受transPRK治疗近视和近视散光的患者被随机分为像差优化模式组（WFO组；36眼）和角膜波前引导模式组（CWFG组；35眼）。比较术前和术后的视力、屈光、对比敏感度和高阶像差。
选取71例接受transPRK的患者（71眼）。术后3个月（P = 0.009；P < 0.001）和6个月时（P = 0.006；P < 0.001），CWFG组角膜像差的总高阶像差和彗差值显著低于WFO组。此外，术后3个月（P = 0.044；P = 0.004）和6个月时（P = 0.026；P = 0.001），CWFG组全眼像差的总高阶像差和彗差值显著低于WFO组。在每度3周/循环（cpd）、6 cpd、12 cpd和18 cpd的空间频率下，CWFG组的对比敏感度改善显著优于WFO组（分别为P = 0.005、P = 0.007、P = 0.001和P < 0.001）。
对于术前像差>0.35μm的眼睛，CWFG transPRK比WFO transPRK具有更好的视觉和屈光效果，且高阶像差更少。
