Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
Pathol Res Pract. 2022 Sep;237:154026. doi: 10.1016/j.prp.2022.154026. Epub 2022 Jul 13.
Prostate Cancer Associated Non-Coding RNA 1 (PRNCR1) is a long non-coding RNA (lncRNA) which is transcribed from chromosome 8, plus strand. This lncRNA has been reported to be an oncogenic transcript participating in the pathogenesis of several kinds of cancers. Some single nucleotide polymorphisms within this lncRNA affect cancer risk. Moreover, few studies have revealed its possible roles in some non-neoplastic conditions, such as cisplatin-induced acute kidney injury, osteolysis after hip replacement, preeclampsia and pulmonary disorders. In the present narrative review, we explain diverse roles of PRNCR1 in human disorders.
前列腺癌相关非编码 RNA 1（PRNCR1）是一种长链非编码 RNA（lncRNA），它由染色体 8 的正链转录而来。据报道，这种 lncRNA 是一种致癌转录本，参与多种癌症的发病机制。该 lncRNA 中的一些单核苷酸多态性会影响癌症风险。此外，很少有研究揭示其在一些非肿瘤性疾病中的可能作用，如顺铂诱导的急性肾损伤、髋关节置换术后骨溶解、子痫前期和肺部疾病。在本叙述性综述中，我们解释了 PRNCR1 在人类疾病中的多种作用。
