Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Biosci Rep. 2018 Jul 31;38(4). doi: 10.1042/BSR20180365. Print 2018 Aug 31.
Several studies have suggested that long non-coding RNA (lncRNA) gene polymorphisms are associated with cancer risk. In the present study, we conducted a meta-analysis related to studies on the association between lncRNA single-nucleotide polymorphisms (SNPs) and the overall risk of cancer. A total of 12 SNPs in five common lncRNA genes were finally included in the meta-analysis. In the lncRNA antisense non-coding RNA (ncRNA) in the INK4 locus (ANRIL), the rs1333048 A/C, rs4977574 A/G, and rs10757278 A/G polymorphisms, but not rs1333045 C/T, were correlated with overall cancer risk. Our study also demonstrated that other SNPs were correlated with overall cancer risk, namely, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1, rs619586 A/G), HOXA distal transcript antisense RNA (HOTTIP, rs1859168 A/C), and highly up-regulated in liver cancer (HULC, rs7763881 A/C). Moreover, four prostate cancer-associated ncRNA 1 (PRNCR1, rs16901946 G/A, rs13252298 G/A, rs1016343 T/C, and rs1456315 G/A) SNPs were in association with cancer risk. No association was found between the PRNCR1 (rs7007694 C/T) SNP and the risk of cancer. In conclusion, our results suggest that several studied lncRNA SNPs are associated with overall cancer risk. Therefore, they might be potential predictive biomarkers for the risk of cancer. More studies based on larger sample sizes and more lncRNA SNPs are warranted to confirm these findings.
几项研究表明，长非编码 RNA（lncRNA）基因多态性与癌症风险相关。本研究进行了一项荟萃分析，涉及 lncRNA 单核苷酸多态性（SNP）与癌症总体风险之间关系的研究。最终纳入了五个常见 lncRNA 基因中的 12 个 SNP 进行荟萃分析。在 INK4 基因座反义非编码 RNA（ncRNA）的 ANRIL 中，rs1333048A/C、rs4977574A/G 和 rs10757278A/G 多态性与总体癌症风险相关，但 rs1333045C/T 多态性与总体癌症风险无关。本研究还表明，其他 SNP 与总体癌症风险相关，即转移相关肺腺癌转录本 1（MALAT1，rs619586A/G）、HOXA 远端转录物反义 RNA（HOTTIP，rs1859168A/C）和肝癌高表达（HULC，rs7763881A/C）。此外，四个前列腺癌相关 ncRNA1（PRNCR1，rs16901946G/A、rs13252298G/A、rs1016343T/C 和 rs1456315G/A）SNP 与癌症风险相关。PRNCR1（rs7007694C/T）SNP 与癌症风险无关。总之，我们的研究结果表明，几种研究的 lncRNA SNP 与癌症的总体风险相关。因此，它们可能是癌症风险的潜在预测生物标志物。需要更多基于更大样本量和更多 lncRNA SNP 的研究来证实这些发现。
