Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University, Richmond, Virginia.
Clin Gastroenterol Hepatol. 2023 Jul;21(7):1957-1959. doi: 10.1016/j.cgh.2022.06.019. Epub 2022 Jul 16.
In chronic hepatitis B virus (HBV) infection, hepatitis B e antigen (HBeAg) and hepatitis B surface antigen (HBsAg) clearance are important milestones toward immune control. A drop in HBV DNA is an established correlate of both HBeAg and HBsAg clearance. We evaluated changes in HBV RNA and hepatitis B core-related antigen (HBcrAg) levels, markers of transcriptional activity of covalently closed circular DNA (cccDNA), with HBeAg and HBsAg clearance, and compared them with changes in HBV DNA level among adult participants in the Hepatitis B Research Network (HBRN).
在慢性乙型肝炎病毒（HBV）感染中，乙型肝炎 e 抗原（HBeAg）和乙型肝炎表面抗原（HBsAg）清除是免疫控制的重要里程碑。HBV DNA 的下降是 HBeAg 和 HBsAg 清除的一个既定相关因素。我们评估了 HBV RNA 和乙型肝炎核心相关抗原（HBcrAg）水平的变化，这些标志物反映了共价闭合环状 DNA（cccDNA）的转录活性，与 HBeAg 和 HBsAg 的清除有关，并与乙型肝炎研究网络（HBRN）中成年参与者的 HBV DNA 水平变化进行了比较。
