Department of Cardiology, Ataturk Training and Research Hospital, Izmir Katip Celebi University, Izmir, Turkey.
Department of Cardiology, Balikesir University Medical School, Balikesir, Turkey.
Eur J Clin Invest. 2022 Oct;52(10):e13834. doi: 10.1111/eci.13834. Epub 2022 Aug 8.
To compare major cardiovascular and cerebrovascular events (MACCE) rates between patients in the pre-COVID-19 era and COVID-19 era, and to assess the impact of the presence of COVID-19 (+) on long-term MACCE in ST-segment elevation myocardial infarction (STEMI) in Turkey.
Using the TURSER study (TURKISH ST-segment elevation myocardial infarction registry) data, the current study included 1748 STEMI patients from 15 centres in Turkey. Patients were stratified into COVID-19 era (March 11st-May 15st, 2020; n = 723) or pre-COVID-19 era (March 11st-May 15st, 2019; n = 1025) cohorts. Long-term MACCE rates were compared between groups. In addition, the effect of COVID-19 positivity on long-term outcomes was evaluated. The primary outcome was the occurrence of MACCE at long-term follow-up, and the secondary outcome was hospitalization with heart failure.
The MACCE and hospitalization with heart failure rates between pre-COVID-19 era and COVID-19 era were 23% versus 22% (p = .841), and 12% versus 8% (p = .002), respectively. In the COVID-19 era, the rates of MACCE and hospitalization with heart failure COVID-19-positive versus COVID-19-negative patients were 40% versus 20%, (p < .001), and 43% versus 11% (p < .001), respectively.
There was no difference between the pre-COVID-19 era and the COVID-19 era in terms of MACCE in STEMI patients in Turkey. In the COVID-19 era, STEMI patients positive for COVID-19 had a higher rate of MACCE and heart failure hospitalization at the long-term follow-up.
比较 COVID-19 前时期和 COVID-19 时期患者的主要心血管和脑血管事件（MACCE）发生率，并评估 COVID-19（+）在土耳其 ST 段抬高型心肌梗死（STEMI）患者中的长期 MACCE 中的影响。
使用 TURSER 研究（土耳其 STEMI 注册研究）的数据，本研究纳入了来自土耳其 15 个中心的 1748 例 STEMI 患者。患者分为 COVID-19 时期（2020 年 3 月 11 日至 5 月 15 日；n=723）或 COVID-19 前时期（2019 年 3 月 11 日至 5 月 15 日；n=1025）队列。比较两组之间的长期 MACCE 发生率。此外，还评估了 COVID-19 阳性对长期结局的影响。主要结局是长期随访时发生 MACCE，次要结局是心力衰竭住院。
COVID-19 前时期和 COVID-19 时期的 MACCE 和心力衰竭住院率分别为 23%和 22%（p=0.841），12%和 8%（p=0.002）。在 COVID-19 时期，COVID-19 阳性和 COVID-19 阴性患者的 MACCE 和心力衰竭住院率分别为 40%和 20%（p<0.001），43%和 11%（p<0.001）。
在土耳其 STEMI 患者中，COVID-19 前时期和 COVID-19 时期的 MACCE 无差异。在 COVID-19 时期，COVID-19 阳性的 STEMI 患者在长期随访时的 MACCE 和心力衰竭住院率更高。
