Chen Chi, Wang Bin, Zhang Haojie, Wang Yuying, Yu Shiyan, Zhou Shuo, Chen Yi, Xia Fangzhen, Zhai Hualing, Wang Ningjian, Lu Yingli
Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, 639, Zhizaoju Road, Shanghai, 200011, China.
Institute of Precision Medicine, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Biol Trace Elem Res. 2023 May;201(5):2266-2273. doi: 10.1007/s12011-022-03357-6. Epub 2022 Jul 18.
We aimed to explore whether an elevated blood lead level (BLL) is associated with visceral adipose dysfunction in patients with type 2 diabetes mellitus (T2DM). Four thousand one hundred and fourteen diabetic participants were enrolled from seven communities in Shanghai in 2018 in the cross-sectional METAL study. BLL was measured by graphite furnace atomic absorption spectrometry. Visceral adiposity index (VAI) and lipid accumulation product (LAP)were calculated by simple anthropometric and biochemical parameters. We found that medians (IQR) of BLL were 26.0 μg/L (18.0-37.0) for men and 25.0 μg/L (18.0-35.0) for women, respectively. In men, each doubling of BLL was associated with a 2.0% higher VAI (95% CI, 0.6 to 3.5%) and 1.8% higher LAP (95% CI, 0.2 to 3.3%) after full adjustment. Using the lowest BLL quartile as the referent group, significant positive trends were observed for BLL with VAI and LAP. In women, each doubling of BLL was associated with a 1.9% higher LAP (95% CI, 0.6 to 3.1%). Additionally, there was a marginally significant positive association between BLL and VAI, either using log2-transformed concentrations as continuous variables or categorized in quartiles. In conclusion, lead exposure is associated with visceral adipose dysfunction in patients with T2DM. Further prospective studies are warranted to confirm our findings.
我们旨在探讨2型糖尿病（T2DM）患者血铅水平（BLL）升高是否与内脏脂肪功能障碍有关。2018年，在横断面METAL研究中，从上海的7个社区招募了4114名糖尿病参与者。通过石墨炉原子吸收光谱法测量BLL。通过简单的人体测量和生化参数计算内脏脂肪指数（VAI）和脂质蓄积产物（LAP）。我们发现，男性的BLL中位数（IQR）为26.0μg/L（18.0 - 37.0），女性为25.0μg/L（18.0 - 35.0）。在男性中，经过全面调整后，BLL每增加一倍，VAI升高2.0%（95%CI，0.6%至3.5%），LAP升高1.8%（95%CI，0.2%至3.3%）。以最低的BLL四分位数作为参照组，观察到BLL与VAI和LAP之间存在显著的正相关趋势。在女性中，BLL每增加一倍，LAP升高1.9%（95%CI，0.6%至3.1%）。此外，无论是将log2转换后的浓度作为连续变量还是按四分位数分类，BLL与VAI之间均存在边缘显著的正相关。总之，铅暴露与T2DM患者的内脏脂肪功能障碍有关。需要进一步的前瞻性研究来证实我们的发现。
