Hameed Ekhlas Khalid, AbdulQahar Zina Hasan
The Clinical Biochemistry Department, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq.
The Clinical Biochemistry Department, College of Medicine, University of Baghdad, Baghdad, Iraq.
Diabetes Metab Syndr. 2019 Mar-Apr;13(2):1241-1244. doi: 10.1016/j.dsx.2019.01.039. Epub 2019 Jan 28.
Visceral Adiposity Index (VAI) is suggested as a surrogate marker for visceral adipose tissue dysfunction. It is an empirical-mathematical model, sex-specific, based on metabolic and anthropometric parameters. Diabetes mellitus is growing in an expanding fashion globally. The aim of this study to study the association between VAI and glycemic control in women with type 2 diabetes mellitus (T2DM).
A total of 300 T2DM female aged (25-60 years) were enrolled in this cross-sectional study. Subjects were recruited from Baghdad medical city during the period from January 2017 to July 2018. Body mass index (BMI), waist circumference (WC), blood pressure was measured and fasting blood sample was analyzed for blood glucose, glycated hemoglobin(HbA1c), and lipid profile. VAI was calculated in addition to triglyceride-glucose (TyG) derived indices. Statistical analysis was done by SPSS version 23. The study was ethically approved.
Patients with high VAI showed poor glycemic control, dyslipidemia, elevated TYG index, TYGWC and TYGBMI. The number of diabetics with poor glycemic control increased across the VAI quartiles. The area under the curve in ROC analysis demonstrated that VAI had a good predictive ability to identify the state of glycemic control as compared to other anthropometric measures (WC, BMI) or combined metabolic and anthropometric measures (TyGWC, TyGBMI).
increased VAI adversely affects the glycemic control in women with T2DM.
内脏脂肪指数(VAI)被认为是内脏脂肪组织功能障碍的替代标志物。它是一个基于代谢和人体测量参数的经验数学模型,具有性别特异性。全球范围内,糖尿病的发病率正在呈上升趋势。本研究旨在探讨2型糖尿病(T2DM)女性患者中VAI与血糖控制之间的关联。
本横断面研究共纳入300名年龄在25至60岁之间的T2DM女性患者。研究对象于2017年1月至2018年7月期间从巴格达医学城招募。测量体重指数(BMI)、腰围(WC)、血压,并采集空腹血样分析血糖、糖化血红蛋白(HbA1c)和血脂谱。除了计算甘油三酯-葡萄糖(TyG)衍生指数外,还计算了VAI。采用SPSS 23版进行统计分析。本研究获得了伦理批准。
VAI高的患者血糖控制差、血脂异常、TyG指数、TyGWC和TyGBMI升高。随着VAI四分位数的增加,血糖控制差的糖尿病患者数量增加。ROC分析中的曲线下面积表明,与其他人体测量指标(WC、BMI)或代谢与人体测量综合指标(TyGWC、TyGBMI)相比,VAI具有良好的预测血糖控制状态的能力。
VAI升高对T2DM女性患者的血糖控制产生不利影响。