Faculty of Veterinary Medicine, Departmnent of Internal Medicine, University of Tehran, Tehran, Iran.
Faculty of Veterinary Medicine, Department of Microbiology and Immunology, University of Tehran, Tehran, Iran.
Vet Med Sci. 2022 Sep;8(5):2119-2125. doi: 10.1002/vms3.888. Epub 2022 Jul 19.
Contagious agalactia (CA) is one of the most important diseases in the small ruminant industry in Iran. The historical aetiology of this disease is Mycoplasma agalactiae (Ma). The main way to control this disease, in addition to management measures, is vaccination. In ruminant newborns, determining the age of first vaccination against Ma is a challenge due to the interference between colostrum-derived maternal immunity and vaccination-induced immunity. The aim of this study was to evaluate the consistency of maternal-derived antibodies specific to the Ma in goat kids blood serum born from the vaccinated does.
Dtermination of level of antibody against Ma in goat kids born from vaccinated dams against Ma. Assessment of duration of protective level of maternal derived antibody in goat kids serum, after receiving colostrum from vaccinted mother with Ma vaccine. Determination the best time vaccination against Ma in goat kids receiving colostrum from vaccinated dams.
20 Saanen goat kids were studied in two groups of 10 animals including control (receiving colostrum from unvaccinated does) and treatment (receiving colostrum from vaccinated does). Indirect Elisa was used to evaluate serum specific antibodies to Ma in goat kids (control and treatment groups) from birth to 100 days of age.
After receiving a sufficient amount of colostrum, the goat kids in the treatment group had a significantly higher S/P% than the control group until 56 days after birth (p < 0.05) and at 70-100 days after birth, there was no significant difference between the treatment and control groups (p > 0.05).
This study showed that 56-70 days of age could be a good age to give the first dose of CA vaccine in goat kids, but more studies are needed on the effectiveness of this vaccine at this age.
传染性乳腺炎（CA）是伊朗小反刍动物产业中最重要的疾病之一。该病的历史病因是无乳支原体（Ma）。除了管理措施外，控制这种疾病的主要方法是接种疫苗。在反刍动物新生儿中，由于初乳衍生的母体免疫和疫苗接种诱导的免疫之间的干扰，确定针对 Ma 的首次疫苗接种的年龄是一个挑战。本研究的目的是评估从接种 Ma 疫苗的母羊中出生的山羊幼崽血清中针对 Ma 的母体衍生抗体的一致性。
确定从接种 Ma 的母羊中出生的山羊幼崽针对 Ma 的抗体水平。评估山羊幼崽血清中母体衍生抗体的保护性水平持续时间，在从接种 Ma 疫苗的母羊中接受初乳后。确定从接种 Ma 的母羊中接受初乳的山羊幼崽接种 Ma 的最佳时间。
在两组 10 只动物中研究了 20 只萨能山羊幼崽，包括对照组（从未接种疫苗的母羊中接受初乳）和治疗组（从接种疫苗的母羊中接受初乳）。间接 ELISA 用于评估山羊幼崽（对照组和治疗组）从出生到 100 天的血清特异性针对 Ma 的抗体。
在接受足够量的初乳后，治疗组的山羊幼崽在出生后 56 天内的 S/P% 显著高于对照组（p < 0.05），而在出生后 70-100 天，治疗组和对照组之间没有显著差异（p > 0.05）。
本研究表明，56-70 天龄可能是山羊幼崽接种 CA 疫苗的最佳年龄，但需要更多研究来评估该年龄段疫苗的有效性。
