Department of Clinical Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.
Department of Quality Control, Razi Vaccine and Serum Research, Education and Extension Organization (AREEO), Karaj, Iran.
J Vet Intern Med. 2024 Sep-Oct;38(5):2801-2806. doi: 10.1111/jvim.17135. Epub 2024 Jul 31.
In goat kids, choosing the appropriate age to administer the first dose of goat pox disease (GTP) vaccine requires knowing when maternal antibody decline concentrations.
Determine the persistence of maternal antibodies against goat pox virus (GTPV) in goat kids.
Twenty Saanen goat kids from birth to 120 days old.
In 2 groups, including: control (receiving colostrum from nonvaccinated does) and treatment (receiving colostrum from vaccinated does). On zero, 3, 7, 14, 21, 28, 42, 56, 70, 100 and 120 days after the birth, virus neutralization test was used to measure the serum concentration of antibodies against GTPV.
At the age of 56 days, the first seronegative goat kids (n = 2) were recorded in the treatment group. At the age of 120 days, all the goat kids in the treatment group were seronegative. The average virus neutralization index (VNI) of the goat kids became negative at the age of 100 to 120 days. All goat kids in the control group were negative at all times.
One hundred to 120 days of the age seems to be the time to administer the first GTP vaccine in the goat kids with passive immunity against goat pox.
在山羊幼崽中，选择首次接种山羊痘病（GTP）疫苗的适当年龄需要了解母体抗体下降浓度。
确定山羊幼崽中针对山羊痘病毒（GTPV）的母体抗体的持续存在。
20 只从出生到 120 天的萨能山羊幼崽。
在 2 组中，包括：对照组（接受未接种疫苗母羊的初乳）和治疗组（接受接种疫苗母羊的初乳）。在出生后第 0、3、7、14、21、28、42、56、70、100 和 120 天，使用病毒中和试验测量针对 GTPV 的血清抗体浓度。
在治疗组中，在 56 天龄时首次记录到 2 只血清阴性的山羊幼崽（n=2）。在 120 天龄时，治疗组的所有山羊幼崽均呈血清阴性。山羊幼崽的平均病毒中和指数（VNI）在 100 至 120 天龄时变为阴性。对照组的所有山羊幼崽在任何时候均呈阴性。
对于具有山羊痘被动免疫力的山羊幼崽，100 至 120 天龄似乎是接种第一剂 GTP 疫苗的时间。
