髋关节软骨 2 年 T 和 T 变化的局部模式与性别和功能数据相关：髋关节骨关节炎参与者的前瞻性评估。
Local Patterns in 2-Year T and T Changes of Hip Cartilage Are Related to Sex and Functional Data: A Prospective Evaluation on Hip Osteoarthritis Participants.
机构信息
Department of Radiology and Biomedical Imaging, University of California-San Francisco, San Francisco, California, USA.
University of California-San Francisco, Department of Physical Therapy and Rehabilitation Science, San Francisco, California, USA.
出版信息
J Magn Reson Imaging. 2023 Apr;57(4):1042-1053. doi: 10.1002/jmri.28347. Epub 2022 Jul 19.
BACKGROUND
Although T and T have emerged as early indicators for hip osteoarthritis (OA), there is little information regarding longitudinal changes across the cartilage in the early stages of this disease.
PURPOSE
To characterize the variability in 2-year hip cartilage T and T changes and investigate associations between these patterns of change and common indicators of hip OA.
STUDY TYPE
Prospective.
POPULATION
A total of 25 women (age: 51.9 ± 16.3 years old; BMI: 22.6 ± 2.0 kg/m ) and 17 men (age: 55.8 ± 14.9 years old; body mass index (BMI): 24.4 ± 3.8 kg/m ) who were healthy or with early-to-moderate hip OA.
FIELD STRENGTH/SEQUENCE: A 3 T MRI (GE), 3D combined T /T magnetization-prepared angle-modulated partitioned k-space spoiled gradient echo snapshots.
ASSESSMENT
Principal component (PC) analysis of Z-score difference maps of 2-year changes in hip cartilage T and T relaxation times, participant hip disability and osteoarthritis outcome scores (HOOS) and functional tests at 2-year follow-up.
STATISTICAL TESTS
Shapiro-Wilk test, unpaired t-tests, Kruskal Wallis tests, Pearson or Spearman (ρ) correlations. Significance was set at P < 0.05.
RESULTS
Women (-6.40 ± 14.48) had significantly lower T PC1 scores than men (10.05 ± 26.15). T PC4 was significantly correlated with HOOS , HOOS , HOOS , HOOS , and HOOS at 2-year follow-up (ρ: [0.36, 0.50]). T PC2 and PC4 were significantly correlated with 30-second chair test (ρ = -0.39 and ρ = 0.24, respectively) and side plank (ρ = -0.32 and ρ = 0.21). T and T PC2 were significantly correlated with 40 m walk test (ρ = 0.34 and ρ = 0.31) and 30-second chair rise test (ρ = -0.39 and ρ = -0.32).
DATA CONCLUSION
Men exhibited accelerated T increases across the femoral cartilage compared to women, suggesting sex should be considered when evaluating early hip OA. Participants with poorer HOOS and function exhibited greater T and T increases in superior and anterior femoral cartilage and greater T increases in the anterior femoral cartilage. These patterns of short-term relaxometry increases could indicate hip OA progression.
EVIDENCE LEVEL
2 TECHNICAL EFFICACY: Stage 3.
背景
T 和 T 已成为髋关节骨关节炎（OA）的早期指标，但关于疾病早期软骨中 T 和 T 的纵向变化的信息很少。
目的
描述髋关节软骨 T 和 T 在 2 年内的变化差异，并探讨这些变化模式与髋关节 OA 常见指标之间的关联。
研究类型
前瞻性研究。
人群
共 25 名女性（年龄：51.9±16.3 岁；BMI：22.6±2.0 kg/m ）和 17 名男性（年龄：55.8±14.9 岁；BMI：24.4±3.8 kg/m ），他们健康或患有早期至中度髋关节 OA。
场强/序列：3T MRI（GE），3D 联合 T/T 磁化准备角度调制分区 K 空间扰动脉冲梯度回波快照。
评估
髋关节软骨 T 和 T 弛豫时间 2 年变化的 Z 分数差图的主成分（PC）分析，2 年随访时的髋关节残疾和骨关节炎结局评分（HOOS）和功能测试。
统计检验
Shapiro-Wilk 检验、配对 t 检验、Kruskal-Wallis 检验、Pearson 或 Spearman（ρ）相关。显著性设为 P<0.05。
结果
女性（-6.40±14.48）的 T PC1 评分明显低于男性（10.05±26.15）。T PC4 与 HOOS 、HOOS 、HOOS 、HOOS 和 2 年随访时的 HOOS 显著相关（ρ：[0.36，0.50]）。T PC2 和 PC4 与 30 秒椅子测试（ρ=-0.39 和 ρ=-0.24）和侧板（ρ=-0.32 和 ρ=-0.21）显著相关。T 和 T PC2 与 40m 步行测试（ρ=0.34 和 ρ=0.31）和 30 秒椅子上升测试（ρ=-0.39 和 ρ=-0.32）显著相关。
数据结论
与女性相比，男性在股骨软骨中 T 增加更快，这表明在评估早期髋关节 OA 时应考虑性别因素。HOOS 和功能较差的参与者在前上股骨软骨中 T 和 T 增加更多，在前股骨软骨中 T 增加更多。这些短期弛豫率增加的模式可能表明髋关节 OA 进展。
证据水平
2 技术功效：第 3 阶段。
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