Department of Animal Biology, School of Life Sciences, University of Hyderabad, Hyderabad, Telangana, India.
Department of Hematology and Oncology, School of Medicine, University of Alabama, Birmingham, Alabama, USA.
J Cell Physiol. 2022 Sep;237(9):3496-3504. doi: 10.1002/jcp.30832. Epub 2022 Jul 19.
The evolutionarily conserved signaling intermediate in toll pathway (ECSIT) is a cytosolic adaptor protein associated with the toll-like receptor pathway. It has a distinct N-terminal mitochondrial targeting sequence, pentatricopeptide repeat motif, and a C-terminal pleckstrin homology domain. ECSIT regulates many biological processes like embryonic development, inflammation, cardiac function, and assembly of mitochondrial complex I. Besides, ECSIT also interacts with multiple signaling intermediates like tumor necrosis receptor associated factor 6 and retinoic acid inducible gene 1 as well as regulates various pathways in the microcellular environment. However, molecular details of ECSIT functions in pathophysiology remain elusive. This review summarizes the diverse functions of ECSIT and its involvement in pathophysiological conditions such as Alzheimer's, oxidative stress, and infection.
ECSIT（toll 通路中进化保守的信号中间体）是一种与 toll 样受体通路相关的胞质衔接蛋白。它具有独特的 N 端线粒体靶向序列、五肽重复基序和 C 端 pleckstrin 同源结构域。ECSIT 调节许多生物学过程，如胚胎发育、炎症、心脏功能和线粒体复合物 I 的组装。此外，ECSIT 还与多种信号中间体相互作用，如肿瘤坏死受体相关因子 6 和维甲酸诱导基因 1，并调节细胞微环境中的各种途径。然而，ECSIT 在病理生理学中的功能的分子细节仍然难以捉摸。这篇综述总结了 ECSIT 的多种功能及其在阿尔茨海默病、氧化应激和感染等病理生理条件下的参与。
