Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mol Genet Genomics. 2022 Sep;297(5):1169-1183. doi: 10.1007/s00438-022-01922-1. Epub 2022 Jul 19.
Long non-coding RNAs (lncRNAs) have become important regulators of gene expression because they affect a wide range of biological processes, such as cell growth, death, differentiation, and aging. More and more evidence suggests that lncRNAs play a role in maintaining metabolic homeostasis. When certain lncRNAs are out of balance, metabolic disorders like diabetes, obesity, and heart disease get worse. In this review, we talk about what we know about how lncRNAs control metabolism, with a focus on diseases caused by long-term inflammation and the characteristics of the metabolic syndrome. We looked at lncRNAs and their molecular targets in the pathogenesis of signaling pathways. We also talked about how lncRNAs are becoming more and more interesting as diagnostic and therapeutic targets for improving metabolic homeostasis.
长非编码 RNA(lncRNA)已成为基因表达的重要调控因子,因为它们影响广泛的生物学过程,如细胞生长、死亡、分化和衰老。越来越多的证据表明,lncRNA 在维持代谢平衡方面发挥作用。当某些 lncRNA 失去平衡时,糖尿病、肥胖症和心脏病等代谢紊乱会变得更糟。在这篇综述中,我们讨论了我们对 lncRNA 如何控制代谢的了解,重点是长期炎症引起的疾病和代谢综合征的特征。我们研究了 lncRNA 及其在信号通路发病机制中的分子靶标。我们还讨论了 lncRNA 如何作为改善代谢平衡的诊断和治疗靶点变得越来越有趣。