Sasaoka Takafumi, Harada Tokiko, Sato Daichi, Michida Nanae, Yonezawa Hironobu, Takayama Masatoshi, Nouzawa Takahide, Yamawaki Shigeto
Center for Brain, Mind, and KANSEI Sciences Research, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Mazda Motor Corporation, 3-1 Shinchi, Fuchu-cho, Aki-gun, Hiroshima, 730-8670, Japan.
Cereb Cortex Commun. 2022 Jun 20;3(3):tgac025. doi: 10.1093/texcom/tgac025. eCollection 2022.
Although the exteroceptive and interoceptive prediction of a negative event increases a person's anxiety in daily life situations, the relationship between the brain mechanism of anxiety and the anxiety-related autonomic response has not been fully understood. In this functional magnetic resonance imaging (fMRI) study, we examined the neural basis of anxiety and anxiety-related autonomic responses in a daily driving situation. Participants viewed a driving video clip in the first-person perspective. During the video clip, participants were presented with a cue to indicate whether a subsequent crash could occur (attention condition) or not (safe condition). Enhanced activities in the anterior insula, bed nucleus of the stria terminalis, thalamus, and periaqueductal gray, and higher sympathetic nerve responses (pupil dilation and peripheral arterial stiffness) were triggered by the attention condition but not with the safe condition. Autonomic response-related functional connectivity was detected in the visual cortex, cerebellum, brainstem, and MCC/PCC with the right anterior insula and its adjacent regions as seed regions. Thus, the right anterior insula and adjacent regions, in collaboration with other regions play a role in eliciting anxiety based on the prediction of negative events, by mediating anxiety-related autonomic responses according to interoceptive information.
尽管在日常生活中，对负面事件的外感受性和内感受性预测会增加一个人的焦虑，但焦虑的脑机制与焦虑相关的自主反应之间的关系尚未完全明确。在这项功能磁共振成像（fMRI）研究中，我们考察了日常驾驶情境中焦虑及焦虑相关自主反应的神经基础。参与者以第一人称视角观看一段驾驶视频片段。在视频片段播放过程中，向参与者呈现一个提示，以表明随后是否可能发生碰撞（注意力条件）或不会发生碰撞（安全条件）。注意力条件而非安全条件触发了前脑岛、终纹床核、丘脑和导水管周围灰质的活动增强，以及更高的交感神经反应（瞳孔扩张和外周动脉僵硬度）。以右侧前脑岛及其相邻区域为种子区域，在视觉皮层、小脑、脑干和内侧前额叶皮质/后扣带回皮质中检测到了自主反应相关的功能连接。因此，右侧前脑岛及其相邻区域与其他区域协作，通过根据内感受信息介导焦虑相关的自主反应，在基于负面事件预测引发焦虑中发挥作用。
