Barrett Lisa Feldman, Quigley Karen S, Hamilton Paul
Department of Psychology, Northeastern University, Boston, MA, USA
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Philos Trans R Soc Lond B Biol Sci. 2016 Nov 19;371(1708). doi: 10.1098/rstb.2016.0011. Epub 2016 Oct 10.
In this paper, we integrate recent theoretical and empirical developments in predictive coding and active inference accounts of interoception (including the Embodied Predictive Interoception Coding model) with working hypotheses from the theory of constructed emotion to propose a biologically plausible unified theory of the mind that places metabolism and energy regulation (i.e. allostasis), as well as the sensory consequences of that regulation (i.e. interoception), at its core. We then consider the implications of this approach for understanding depression. We speculate that depression is a disorder of allostasis, whose myriad symptoms result from a 'locked in' brain that is relatively insensitive to its sensory context. We conclude with a brief discussion of the ways our approach might reveal new insights for the treatment of depression.This article is part of the themed issue 'Interoception beyond homeostasis: affect, cognition and mental health'.
在本文中，我们将预测编码和内感受的主动推理理论（包括具身预测内感受编码模型）的最新理论与实证进展，与建构情绪理论中的工作假设相结合，提出一种具有生物学合理性的统一心智理论，该理论将新陈代谢和能量调节（即内稳态）以及该调节的感觉后果（即内感受）置于核心位置。然后，我们思考这种方法对理解抑郁症的意义。我们推测，抑郁症是一种内稳态紊乱，其众多症状源于大脑“陷入困境”，对其感觉环境相对不敏感。最后，我们简要讨论了我们的方法可能为抑郁症治疗带来新见解的方式。本文是主题为“超越内稳态的内感受：情感、认知与心理健康”的特刊的一部分。
