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Adiponectin, a unique adipocyte-derived factor beyond hormones.脂联素：一种独特的脂肪细胞衍生因子，超越了激素的范畴。
Atherosclerosis. 2020 Jan;292:1-9. doi: 10.1016/j.atherosclerosis.2019.10.021. Epub 2019 Nov 2.
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Ethnic and Sex Differences in Adiponectin: From Childhood to Adulthood.脂联素的种族和性别差异：从儿童期到成年期
J Clin Endocrinol Metab. 2016 Dec;101(12):4808-4815. doi: 10.1210/jc.2016-1137. Epub 2016 Sep 7.
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Addition of Exercise Increases Plasma Adiponectin and Release from Adipose Tissue.增加运动可提高血浆脂联素水平并促进脂肪组织释放脂联素。
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New insight into adiponectin role in obesity and obesity-related diseases.对脂联素在肥胖和肥胖相关疾病中的作用的新认识。
Biomed Res Int. 2014;2014:658913. doi: 10.1155/2014/658913. Epub 2014 Jul 7.
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Activation of nuclear receptor NR5A2 increases Glut4 expression and glucose metabolism in muscle cells.核受体 NR5A2 的激活可增加肌肉细胞中的 Glut4 表达和葡萄糖代谢。
Biochem Biophys Res Commun. 2014 Apr 4;446(2):614-9. doi: 10.1016/j.bbrc.2014.03.010. Epub 2014 Mar 12.
6
Aerobic exercise + weight loss decreases skeletal muscle myostatin expression and improves insulin sensitivity in older adults.有氧运动+减肥可降低老年人骨骼肌中肌肉生长抑制素的表达，改善胰岛素敏感性。
Obesity (Silver Spring). 2013 Jul;21(7):1350-6. doi: 10.1002/oby.20216. Epub 2013 May 19.
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Gender differences in serum high-molecular-weight adiponectin levels in metabolic syndrome.代谢综合征患者血清高分子量脂联素水平的性别差异。
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LRH-1-dependent glucose sensing determines intermediary metabolism in liver.LRH-1 依赖性葡萄糖感应决定肝脏中的中间代谢。
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Exercise with calorie restriction improves insulin sensitivity and glycogen synthase activity in obese postmenopausal women with impaired glucose tolerance.运动结合热量限制可改善葡萄糖耐量受损的肥胖绝经后妇女的胰岛素敏感性和糖原合酶活性。
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脂联素和肝脏受体同源物-1在脂肪组织和骨骼肌中的表达与体重减轻及有氧运动的关系

Adipose and Skeletal Muscle Expression of Adiponectin and Liver Receptor Homolog-1 With Weight Loss and Aerobic Exercise.

作者信息

Ryan Alice S, Li Guoyan

机构信息

VA Research Service, VA Maryland Health Care System, Baltimore, Maryland 21201, USA.

Department of Medicine, Division of Geriatric and Palliative Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.

出版信息

J Endocr Soc. 2022 Jul 1;6(8):bvac095. doi: 10.1210/jendso/bvac095. eCollection 2022 Aug 1.

DOI:10.1210/jendso/bvac095
PMID:35854979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9281870/
Abstract

CONTEXT

Adiponectin is an adipokine mainly secreted by adipocytes that regulates the metabolism of lipids and glucose. Liver receptor homolog-1 (LRH-1), also named NR5A2, is a nuclear receptor that regulates lipid metabolism and homeostasis.

OBJECTIVE

The purpose of this study was to compare adiponectin and LRH-1 messenger RNA (mRNA) expression in adipose tissue and LRH-1 expression in skeletal muscle between men and women at baseline and to study the effects of aerobic exercise (AEX) training or weight loss (WL) on their expression.

METHODS

This hospital and university setting study included 62 overweight and obese men (n = 23) and women (n = 39) older than 45 years, of whom 41 completed 6 months of WL (n = 21) or AEX (n = 20). Outcomes included abdominal and gluteal adipose tissue and skeletal muscle gene expression.

RESULTS

Adiponectin and LRH-1 mRNA expression in adipose tissue and LRH-1 mRNA expression in skeletal muscle is higher in women than in men ( < .05). Adiponectin mRNA expression in gluteal and abdominal adipose tissue did not change significantly after AEX or WL. LRH-1 mRNA expression increased both in adipose tissue and skeletal muscle after AEX ( < .05) and the change in muscle LRH-1 was different between the groups ( < .05). Adiponectin was positively correlated to LRH-1 in adipose tissue ( < .001). The change in maximal oxygen consumption related to the change in LRH-1 mRNA ( = 0.43;  = .01).

CONCLUSION

LRH-1, as a nuclear reporter, may activate adiponectin mRNA expression in adipose tissue and increases after AEX.

摘要

背景

脂联素是一种主要由脂肪细胞分泌的脂肪因子，可调节脂质和葡萄糖代谢。肝脏受体同源物1（LRH-1），也称为NR5A2，是一种调节脂质代谢和体内平衡的核受体。

目的

本研究旨在比较男性和女性在基线时脂肪组织中脂联素和LRH-1信使核糖核酸（mRNA）的表达以及骨骼肌中LRH-1的表达，并研究有氧运动（AEX）训练或减肥（WL）对其表达的影响。

方法

这项医院和大学联合开展的研究纳入了62名年龄超过45岁的超重和肥胖男性（n = 23）和女性（n = 39），其中41人完成了6个月的WL（n = 21）或AEX（n = 20）。观察指标包括腹部和臀部脂肪组织以及骨骼肌的基因表达。

结果

女性脂肪组织中脂联素和LRH-1 mRNA的表达以及骨骼肌中LRH-1 mRNA的表达均高于男性（P <.05）。AEX或WL后，臀肌和腹部脂肪组织中脂联素mRNA的表达无显著变化。AEX后，脂肪组织和骨骼肌中LRH-1 mRNA的表达均增加（P <.05），且两组肌肉中LRH-1的变化存在差异（P <.05）。脂肪组织中脂联素与LRH-1呈正相关（P <.001）。最大耗氧量的变化与LRH-1 mRNA的变化相关（r = 0.43；P =.01）。

结论

LRH-1作为一种核报告基因，可能激活脂肪组织中脂联素mRNA的表达，并在AEX后增加。