Ke Chao, Shan Shengtao, Fang Chuang, Xia Yewan, Zhang Wei
The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410007, China.
Evid Based Complement Alternat Med. 2022 Jul 9;2022:8243704. doi: 10.1155/2022/8243704. eCollection 2022.
This review aims to systematically summarize and analyze recent high-quality animal research results about the use of acupuncture in Alzheimer's disease (AD) patients. This information will be useful in providing a reference for future experimental research and an experimental basis for the clinical use of acupuncture in the treatment of AD.
We utilized and referenced various electronic libraries from their inception to November 2021. Relevant information was reviewed and information such as the journal names, publication records, animal model selections and preparations, intervention measures, acupoint selections, detection methods, and detection indicators was extracted. Results. A total of 75 eligible studies were selected for additional review. Male SAMP8 mice, APP/PS1 double transgenic mice, Sprague-Dawley (SD) rats, and Wistar rats were the four commonly used animal strains in the experiments. The animals were categorized as transgenic and surgical mouse models. Experimental interventions included manual acupuncture (MA), Electro-acupuncture (EA), Moxibustion, and EA combined with Moxibustion. A retention time of 20 min was the optimal timing for experimental studies, with 14 sessions chosen as the most common treatment time. EA was the most prescribed acupuncture treatment type with continuous wave, 2 Hz frequency, and 1 mA electric current selected as frequently used parameters. A total of 78 acupoint prescriptions were analyzed involving 21 acupoints. The top 3 combinations of common acupoints were GV20 ⟶ EX-HN3, GV20 ⟶ BL23, and GV20 ⟶ GV26. A total of 39 articles had positive drug control groups, sham acupuncture, and/or nonacupoint control groups. Furthermore, 10 types of behavioral tests, 29 detection methods, 178 evaluation indicators, and 18 tissue samples were included in the analysis.
By collating these high-quality research studies systematically and comprehensively, acupuncture was found to be a viable and effective treatment in AD animal models. In addition, when designing experiments, researchers could refer to the detailed data provided here to make better schemes and maybe conduct more investigations in unresearched areas.
本综述旨在系统总结和分析近期关于针刺治疗阿尔茨海默病（AD）患者的高质量动物研究结果。这些信息将有助于为未来的实验研究提供参考，并为针刺治疗AD的临床应用提供实验依据。
我们利用并参考了从各电子数据库建立之初到2021年11月的资料。对相关信息进行了综述，并提取了诸如期刊名称、发表记录、动物模型选择与制备、干预措施、穴位选择、检测方法和检测指标等信息。结果：共筛选出75项符合条件的研究进行进一步综述。雄性SAMP8小鼠、APP/PS1双转基因小鼠、Sprague-Dawley（SD）大鼠和Wistar大鼠是实验中常用的四种动物品系。这些动物被分为转基因和手术小鼠模型。实验干预包括手针（MA）、电针（EA）、艾灸以及电针结合艾灸。20分钟的留针时间是实验研究的最佳时长，14次治疗是最常见的治疗次数。电针是最常用的针刺治疗类型，常用参数为连续波、2Hz频率和1mA电流。共分析了78个穴位处方，涉及21个穴位。常用穴位的前三大组合为GV20⟶EX-HN3、GV20⟶BL23和GV20⟶GV26。共有39篇文章设有阳性药物对照组、假针刺组和/或非穴位对照组。此外，分析还包括10种行为测试、29种检测方法、178个评估指标和18种组织样本。
通过系统全面地整理这些高质量研究，发现针刺在AD动物模型中是一种可行且有效的治疗方法。此外，在设计实验时，研究人员可以参考此处提供的详细数据来制定更好的方案，并可能在未研究的领域进行更多调查。
