Wang Wei, Yang Qing, Xun Qiufen, Ye Xiaoqun
Department of Respiratory, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
Evid Based Complement Alternat Med. 2022 Jul 9;2022:1183436. doi: 10.1155/2022/1183436. eCollection 2022.
To investigate the patients with stable chronic obstructive pulmonary disease (COPD) to understand the use of double bronchodilator therapy and influencing factors.
The patients with stable COPD who used double bronchodilators were continuously enrolled in our hospital. The information of demographic characteristics, medical history, physical examination, drug use, and correct treatment methods after using inhaled drugs were collected by standardized questionnaire. Measurement data between groups were compared by using the independent sample -test, and counting data between groups were compared by using the chi-square test.
A total of 102 patients were included in the analysis. The proportion of patients with stable COPD who correctly used dual bronchodilators was 59.8% (61 patients). In the GOLD classification, the correct use rate of C-level patients was 69.8%, which was significantly higher than the used correct rate of D-level patients (49.0%) (=0.032). In the age group, the correct use rate of patients <65 years old was 72.1%, which was significantly higher than that of patients ≥65 years old (50.8%) (=0.031). In addition, education level, duration of drug use, and drug type may also affect the correct use of drugs, but no significant statistical significance was found between the groups of these three factors ( > 0.05).
There is still a gap between the treatment of dual bronchodilators in patients with stable COPD and the guidelines, so the management of COPD should be strengthened. Besides, the correct use rate could be affected by the GOLD classification and age.
调查稳定期慢性阻塞性肺疾病(COPD)患者,以了解双支气管扩张剂治疗的使用情况及影响因素。
连续纳入我院使用双支气管扩张剂的稳定期COPD患者。通过标准化问卷收集人口统计学特征、病史、体格检查、用药情况以及吸入药物后正确治疗方法的信息。组间计量资料比较采用独立样本t检验,组间计数资料比较采用卡方检验。
共纳入102例患者进行分析。稳定期COPD患者正确使用双支气管扩张剂的比例为59.8%(61例)。在GOLD分级中,C级患者的正确使用率为69.8%,显著高于D级患者的正确使用率(49.0%)(P = 0.032)。在年龄组中,<65岁患者的正确使用率为72.1%,显著高于≥65岁患者(50.8%)(P = 0.031)。此外,教育程度、用药时长和药物类型可能也会影响药物的正确使用,但这三个因素组间比较差异均无统计学意义(P>0.05)。
稳定期COPD患者双支气管扩张剂治疗与指南之间仍存在差距,因此应加强COPD的管理。此外,正确使用率可能受GOLD分级和年龄的影响。