Department of Pediatrics, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314033, China.
Rehabilitation Center, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314033, China.
Comput Math Methods Med. 2022 Jul 9;2022:6465060. doi: 10.1155/2022/6465060. eCollection 2022.
Cerebral palsy (CP) has a serious impact on children's multiple motor functions and life behavior. Rehabilitation therapy or pharmacotherapy alone has been proven to have a good effect on patients' strength and gait. However, the efficacy of rehabilitation combined with pharmacotherapy for CP in children needs to be further explored. This study is aimed at assessing the effectiveness of this combined method on life function and social behavior in children with CP.
PubMed, China National Knowledge Infrastructure, WanFang Data, EMBASE, and Web of Science databases were searched for all kinds of literature related to the treatment of pediatric CP published between 2000 and 2021. Basic information and experimental data from the literature were screened and extracted, and a meta-analysis was performed using Stata 16.
A total of 605 studies were retrieved, and finally, 10 studies involving 805 pediatric patients were included in the analysis. The analysis results showed that rehabilitation combined with pharmacotherapy could improve the treatment effective rate in children with CP compared with the control group using either alone (RR = 1.184, 95% CI (1.102, 1.273), < 0.001). In addition, in terms of social behavior, the combined therapy could significantly improve activities of daily living (SMD = 2.94, 95% CI (1.66, 4.22), < 0.001), motor ability (SMD = 1.86, 95% CI (0.75, 2.96), = 0.001), adaptability behavior (SMD = 2.82, 95% CI (0.45, 5.18), = 0.019), language behavior (SMD = 3.08, 95% CI (0.95, 5.22), = 0.005), social behavior (SMD = 3.78, 95% CI (2.22, 5.35), < 0.001), and fine motor behavior (SMD = 3.52, 95% CI (1.17, 5.86), = 0.003).
The current study shows that rehabilitation combined with pharmacotherapy can effectively improve the recovery, quality of life, and social behavior of children with CP.
脑瘫（CP）严重影响儿童的多项运动功能和生活行为。已证实康复疗法或药物疗法单独使用对患者的力量和步态有良好的效果。然而，康复联合药物治疗儿童 CP 的疗效仍需进一步探讨。本研究旨在评估该联合方法对 CP 儿童生活功能和社会行为的疗效。
检索 2000 年至 2021 年间发表的与儿科 CP 治疗相关的各种文献，包括 PubMed、中国知网、万方数据、EMBASE 和 Web of Science 数据库。筛选文献的基本信息和实验数据，并使用 Stata 16 进行荟萃分析。
共检索到 605 项研究，最终纳入 10 项研究，共 805 例儿科患者。分析结果显示，与单独使用药物或康复治疗相比，康复联合药物治疗可提高 CP 儿童的治疗有效率（RR = 1.184，95%CI（1.102，1.273），<0.001）。此外，在社会行为方面，联合治疗可显著提高日常生活活动能力（SMD = 2.94，95%CI（1.66，4.22），<0.001）、运动能力（SMD = 1.86，95%CI（0.75，2.96），= 0.001）、适应行为（SMD = 2.82，95%CI（0.45，5.18），= 0.019）、语言行为（SMD = 3.08，95%CI（0.95，5.22），= 0.005）、社会行为（SMD = 3.78，95%CI（2.22，5.35），<0.001）和精细运动行为（SMD = 3.52，95%CI（1.17，5.86），= 0.003）。
本研究表明，康复联合药物治疗可有效改善 CP 儿童的康复、生活质量和社会行为。
