Research Center, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.
Hebei Provincial Key Laboratory of Tumor Microenvironment and Drug Resistance, Hebei Medical University, Shijiazhuang 050017, China.
Dis Markers. 2022 Jul 9;2022:1094597. doi: 10.1155/2022/1094597. eCollection 2022.
To investigate into the clinical factors associated with posttreatment recurrence and death patterns in patients with advanced esophageal cancer.
Clinical information of patients with recurrence/metastasis and death after radical resection of esophageal cancer at our hospital between January 1, 2005, and December 31, 2015, were retrospectively collected and followed up. Postoperative recurrence-free survival time, postrelapse survival time, and overall survival time were compared among the metabolic-associated, organ failure-associated, and anastomotic recurrence-associated mortality groups.
Five hundred and ninety-five qualified patients were retrieved, including 456 males and 139 females, with an average age of 58 ± 7.56 years. There were 57 cases of TNM-1 stage, 131 cases of TNM-2 stage, 365 cases of TNM-3 stage, and 42 cases of TNM-4 stage. There were 547 cases of squamous cell cancer and 48 cases of nonsquamous cell cancer. There were significant differences in age ( < 0.01), tumor location ( < 0.01), and lymph node metastasis ( = 0.04), recurrence type ( < 0.01) by one-way ANOVA, and recurrence-free survival ( = 0.02) and postrecurrence survival ( < 0.01) by Kaplan-Meier survival curve analysis among the three main death causes.
Age, tumor location, and lymph node metastasis were significantly different among metabolic-associated, organ failure-associated, and anastomotic recurrence-associated mortality of recurrent EC patients.
探讨晚期食管癌患者治疗后复发和死亡模式与临床因素的关系。
回顾性收集我院 2005 年 1 月 1 日至 2015 年 12 月 31 日根治性切除食管癌后复发/转移和死亡的患者临床资料并随访。比较代谢相关、器官衰竭相关和吻合口复发相关死亡组的术后无复发生存时间、复发后生存时间和总生存时间。
共检索到 595 例合格患者，其中男 456 例，女 139 例，平均年龄 58±7.56 岁。TNM-1 期 57 例，TNM-2 期 131 例，TNM-3 期 365 例，TNM-4 期 42 例。鳞癌 547 例，非鳞癌 48 例。单因素方差分析显示，年龄（<0.01）、肿瘤部位（<0.01）和淋巴结转移（=0.04）差异有统计学意义，Kaplan-Meier 生存曲线分析显示，复发类型（<0.01）、无复发生存（=0.02）和复发后生存（<0.01）差异有统计学意义。
代谢相关、器官衰竭相关和吻合口复发相关的 EC 患者死亡的主要原因与年龄、肿瘤位置和淋巴结转移有显著差异。
