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对2019冠状病毒病疫苗研发的洞察:从实验室到临床的转化

Insights into COVID-19 vaccines development: Translation from benchside to bedside.

作者信息

Houssein Marwa, Al Hossainy Aya El Asir, Al Soussi Jana, El Batch Jana, El-Samadi Lana, El Imam Sherine, Fakih Rawan, Dakdouk Hoda, Khalil Mahmoud

机构信息

Department of Biological Sciences, Faculty of Science, Beirut Arab University, Beirut, Lebanon.

Department of General Sciences and English Language, College of Applied Sciences, Al Maarefa University, Riyadh, Saudi Arabia.

出版信息

Health Sci Rev (Oxf). 2022 Sep;4:100040. doi: 10.1016/j.hsr.2022.100040. Epub 2022 Jul 10.

Abstract

Over the past decades, the rapid pace of vaccine development saved 37 million lives, mostly children. The ongoing corona virus disease (COVID-19) pandemic caused the death of more than 4 million worldwide. During 2020, to encounter the pandemic, scientists developed more than 300 vaccines projects against SARS-CoV (severe acute respiratory syndrome coronavirus 2). In 2021, the results emerging from the clinical trials led to the approval and rollout of few vaccines in different countries. To date, at least one dose of a COVID-19 vaccine has been received by more than 3.81 billion people worldwide, equal to about 49.7 percent of the world population. This review was written to the aim of providing a snapshot of COVID-19 disease, highlighting the well-known vaccines, and, finally understanding the effect of mix and match vaccines from different types.

摘要

在过去几十年里,疫苗研发的快速步伐挽救了3700万人的生命,其中大多数是儿童。目前的冠状病毒病(COVID-19)大流行在全球造成了400多万人死亡。2020年期间,为应对这一流行病,科学家们开展了300多个针对严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的疫苗项目。2021年,临床试验的结果导致少数疫苗在不同国家获得批准并推出。迄今为止,全球超过38.1亿人至少接种了一剂COVID-19疫苗,约占世界人口的49.7%。撰写这篇综述的目的是提供COVID-19疾病的概况,突出知名疫苗,并最终了解不同类型混合搭配疫苗的效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b59/9271228/11321e495a6b/gr1_lrg.jpg

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