Das Piyanki, Chattopadhyay Nabanita Roy, Chatterjee Koustav, Choudhuri Tathagata
Department of Biotechnology, Siksha-Bhavana, Visva-Bharati, Santiniketan, West Bengal 731235 India.
Virusdisease. 2020 Sep;31(3):209-219. doi: 10.1007/s13337-020-00573-3. Epub 2020 Mar 22.
Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with viral malignancy, related to HIV-AIDS. With a wide geographical discrimination in its occurrence, Asian countries shows low to moderate prevalence with higher occurrence in some particular areas. India is one of the largest countries in Asia, having various geographical and cultural variations where KSHV has been considered as an unthinkable entity to cause any of its associated disease. India has been reported as a low prevalent zone for KSHV malignancy till date. Also there are no reports so far, describing the occurrence pattern of this malignancy. So this review approaches towards figuring out the tendency of prevalence pattern of this malignancy and associated risk factors found to be present in Indian population. From this study it is revealed that, KSHV related malignancy is a relatively newly reported and emerging disease in India and may exist in hidden pockets throughout India in association with tuberculosis. India shows prevalence in HIV-associated Kaposi's sarcoma in regions where socially discriminated LGBT (lesbian, gay, bisexual, and transgender) groups, unprotected sexual behavior and heterosexuality are the important risk factors for sexually transmitted viral diseases. Anti-retro viral therapy is not sufficient to combat the virus and may act adversely. On a note regarding the clinical representations of Kaposi's sarcoma, oral, mucosal, pleural and abdominal involvements are observed in worst cases and these can be considered as the main manifesting criteria for this malignancy among Indians.
卡波西肉瘤相关疱疹病毒（KSHV）与病毒恶性肿瘤有关，与HIV-艾滋病相关。其发病存在广泛的地域差异，亚洲国家的患病率较低至中等，在一些特定地区发病率较高。印度是亚洲最大的国家之一，有各种地理和文化差异，在印度，KSHV被认为是引发其任何相关疾病的不可思议的因素。迄今为止，印度一直被报道为KSHV恶性肿瘤的低发区。此外，到目前为止，也没有关于这种恶性肿瘤发病模式的报道。因此，本综述旨在找出这种恶性肿瘤的流行模式趋势以及印度人群中发现的相关危险因素。从这项研究中可以看出，KSHV相关恶性肿瘤在印度是一种相对较新报道的新兴疾病，可能与结核病一起存在于印度各地的隐蔽地区。在印度，HIV相关的卡波西肉瘤在一些地区有流行，在这些地区，受到社会歧视的 LGBT（女同性恋、男同性恋、双性恋和跨性别者）群体、无保护的性行为和异性性行为是性传播病毒疾病的重要危险因素。抗逆转录病毒疗法不足以对抗这种病毒，而且可能产生不利影响。关于卡波西肉瘤的临床表现，在最严重的病例中可观察到口腔、黏膜、胸膜和腹部受累，这些可被视为印度人这种恶性肿瘤的主要表现标准。
