Department of Dermatovenereology, Second Faculty of Medicine, Charles University, Bulovka University Hospital, Prague, Czech Republic.
Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Hradec Králové, Charles University, Faculty of Medicine in Hradec Králové, Hradec Králové, Czech Republic.
J Dermatolog Treat. 2022 Nov;33(7):3063-3065. doi: 10.1080/09546634.2022.2104442. Epub 2022 Jul 26.
Mucocutaneous mycotic infections are common complications in patients on IL-17 inhibitor therapy. We report a case of a 33-year-old male with severe psoriasis and psoriatic arthritis on secukinumab combined with methotrexate and prednisone with swelling, otorrhea, and pain of the right ear and external auditory canal. Due to progressive hypacusis, a surgical solution was chosen. Tissue samples taken during surgery revealed the presence of . Aspergillosis should be suspected in prolonged otorrhea, especially in immunocompromised patients. Without intervention, the disease could be fatal.
黏膜皮肤真菌感染是接受白细胞介素-17 抑制剂治疗的患者的常见并发症。我们报告了一例 33 岁男性患者，患有严重的银屑病和银屑病关节炎，正在接受司库奇尤单抗联合甲氨蝶呤和泼尼松治疗，出现右侧耳肿胀、耳漏和疼痛以及外耳道疼痛。由于听力逐渐下降，选择了手术治疗。手术过程中采集的组织样本显示存在. 对于持续性耳漏，尤其是免疫功能低下的患者，应怀疑曲霉病。如果不进行干预，疾病可能是致命的。
