National Institute of Public Health, Ljubljana, Slovenia (Centre for Communicable Diseases).
National Laboratory for Health, Food and Environment, Ljubljana, Slovenia (Laboratory for Public Health Virology).
Int J Occup Med Environ Health. 2022 Oct 3;35(5):571-584. doi: 10.13075/ijomeh.1896.01932. Epub 2022 Jul 15.
The pandemic caused by the novel coronavirus (SARS-CoV-2) affected a disproportionately high percentage of healthcare workers (HCWs). The aim of the study was to assess the seroprevalence of SARS-CoV-2-specific IgG antibodies in nurses and clinicians working in 2 Slovenian regional hospitals, and to identify the factors associated with seropositivity.
The study was designed as a crosssectional study. Clinicians and nurses were invited to participate in November-December 2020. The respondents (813, 65.8%) completed a questionnaire and consented to provide 10 ml of blood for determining the presence of SARS-CoV-2 IgG antibodies.
The authors observed a seroprevalence rate of 20.4%. The results of the univariate analysis proved that the age of a nurse or clinician was the factor most strongly associated with seropositivity - in fact, the youngest nurses and clinicians were 8.33 times more likely to be seropositive than those in the oldest age group (p = 0.041). Being in contact with a family/household member who was SARS-CoV-2-positive was also a very important factor. In the work-related factors group, being in the contact with a SARS-CoV-2-positive colleague (OR = 2.35, p = 0.026) or being in contact with a COVID-19 patient (OR = 1.96, p = 0.004) correlated with seropositivity. In the primary work location/department group, the only significant association appeared among those working in surgical, ENT or ophthalmology departments. The results of the multivariate analysis further supported the thesis that the age of nurses and clinicians was the factor most strongly associated with seropositivity. The youngest nurses and clinicians were 12.5 times more likely to be seropositive than those in the oldest age group (p = 0.024). Being in contact with a SARS-CoV-2-positive family/household member remained the second most important factor.
A significant number of clinicians and nurses working in secondary healthcare were infected in the first 9 months of the pandemic. Int J Occup Med Environ Health. 2022;35(5):571-84.
由新型冠状病毒（SARS-CoV-2）引起的大流行 disproportionately 影响了高比例的医护人员（HCWs）。本研究的目的是评估在斯洛文尼亚的两家地区医院工作的护士和临床医生中 SARS-CoV-2 特异性 IgG 抗体的血清流行率，并确定与血清阳性相关的因素。
该研究设计为横断面研究。在 2020 年 11 月至 12 月期间，邀请临床医生和护士参加。813 名应答者（65.8%）完成了一份问卷，并同意提供 10 毫升血液以确定 SARS-CoV-2 IgG 抗体的存在。
作者观察到血清阳性率为 20.4%。单因素分析的结果证明，护士或临床医生的年龄是与血清阳性最密切相关的因素-实际上，年龄最小的护士和临床医生比年龄最大的年龄组阳性的可能性高 8.33 倍（p = 0.041）。与 SARS-CoV-2 阳性家庭成员/家庭成员接触也是一个非常重要的因素。在与工作相关的因素组中，与 SARS-CoV-2 阳性同事接触（OR = 2.35，p = 0.026）或与 COVID-19 患者接触（OR = 1.96，p = 0.004）与血清阳性相关。在主要工作地点/部门组中，仅在外科、耳鼻喉科或眼科部门工作的人之间存在显著关联。多因素分析的结果进一步支持了护士和临床医生的年龄是与血清阳性最密切相关的因素的观点。年龄最小的护士和临床医生阳性的可能性比年龄最大的年龄组高 12.5 倍（p = 0.024）。与 SARS-CoV-2 阳性家庭成员/家庭成员接触仍然是第二重要的因素。
在大流行的前 9 个月，在二级医疗机构工作的大量临床医生和护士感染。国际职业医学与环境卫生杂志。2022;35(5):571-84。
