De Geyter Deborah, Vancutsem Ellen, Van Laere Sven, Piérard Denis, Lacor Patrick, Weets Ilse, Allard Sabine
Clinical Biology, Laboratory of Microbiology and Infection Control, Universitair Ziekenhuis Brussel, Brussels, Belgium.
Biostatitics and Medical Informatics, Faculty of Medicine and Farmacy, Vrije Universiteit Brussel, Brussels, Belgium.
Epidemiol Infect. 2021 Jul 5;149:1-24. doi: 10.1017/S0950268821001540.
Between 19 May and 12 June 2020, employees of the UZ Brussel were recruited in this study aiming to document the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence, to investigate the potential work-related risk factors for SARS-CoV-2 infection and to estimate the proportion of asymptomatic infections. In total, 2662 participants were included of whom 7.4% had immunoglobulin G antibodies against SARS-CoV-2. Of the participants reporting a positive polymerase chain reaction for SARS-CoV-2, 89% had antibodies at the time of blood sampling. Eleven per cent of the antibody positive participants reported no recent symptoms suggestive of coronavirus disease 2019 (COVID-19). Participants reporting fever, chest pain and/or anosmia/ageusia were significantly more frequently associated with the presence of antibodies against SARS-CoV-2. The presence of antibodies was highest in the group that had had contact with COVID-19-infected individuals outside the hospital with or without using appropriate personnel protective equipment (PPE) ( < 0.001). Inside the hospital, a statistically significant difference was observed for the employees considered as low-risk exposure compared to the intermediate-risk exposure group ( = 0.005) as well as the high-risk exposure group compared to the intermediate exposure risk group ( < 0.001). These findings highlight the importance of using correct PPE.
2020年5月19日至6月12日，布鲁塞尔大学医院的员工参与了这项研究，旨在记录严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的血清流行率，调查SARS-CoV-2感染潜在的工作相关风险因素，并估计无症状感染的比例。总共纳入了2662名参与者，其中7.4%的人具有抗SARS-CoV-2的免疫球蛋白G抗体。在报告SARS-CoV-2聚合酶链反应呈阳性的参与者中，89%在采血时已有抗体。11%抗体呈阳性的参与者报告近期无提示2019冠状病毒病（COVID-19）的症状。报告发热、胸痛和/或嗅觉减退/味觉减退的参与者与抗SARS-CoV-2抗体的存在显著更相关。在与医院外COVID-19感染者有接触的组中，无论是否使用适当的个人防护装备（PPE），抗体的存在率最高（<0.001）。在医院内部，与中风险暴露组相比，低风险暴露的员工存在统计学显著差异（=0.005），与中风险暴露组相比，高风险暴露组也存在统计学显著差异（<0.001）。这些发现突出了使用正确PPE的重要性。
