Division of Genetics, Department of Biology, Friedrich-Alexander University Erlangen-Nürnberg, Erwin-Rommelstr. 3, Erlangen 91058, Germany.
Medical Immunology Campus Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erwin-Rommelstr. 3, Erlangen 91058, Germany.
Sci Immunol. 2022 Jul 15;7(73):eabq4797. doi: 10.1126/sciimmunol.abq4797. Epub 2022 Jul 8.
Two recent studies in by Orr and Foss demonstrate that the hinge region of immunoglobulin G (IgG) is a major regulator of IgG2 and IgG3 activity, respectively. Engineering of the IgG hinge may therefore be useful for optimizing the activity of IgG subclasses.
最近由 Orr 和 Foss 在《》发表的两项研究表明，免疫球蛋白 G（IgG）的铰链区分别是 IgG2 和 IgG3 活性的主要调节因子。因此，对 IgG 铰链区进行工程改造可能有助于优化 IgG 亚类的活性。
