中国儿童血清 IgG 亚类参考区间。
A reference interval for serum IgG subclasses in Chinese children.
机构信息
Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
出版信息
PLoS One. 2018 Mar 5;13(3):e0192923. doi: 10.1371/journal.pone.0192923. eCollection 2018.
BACKGROUND
Reference intervals (RIs) for serum IgG subclasses vary greatly among different geographical regions. The present study aimed to establish RIs for serum IgG subclasses in Chinese children, which is essential for interpretation of laboratory findings and making clinical decisions.
METHODS
This study was performed in accordance with guideline C28-A3, proposed by the International Federation of Clinical Chemistry and the Clinical and Laboratory Standards Institute. In total, 607 apparently healthy Chinese children were enrolled, and serum levels of IgG subclasses were measured. Individuals were stratified by age and the RIs were determined through statistical analysis.
RESULTS
Following were the median values of RIs for serum IgG subclasses in Chinese children: IgG1, 2.78 g/L; IgG2, 0.85 g/L; IgG3, 0.13 g/L; IgG4, 0.06 g/L at 1-6 months of age; IgG1, 3.64 g/L; IgG2, 0.73 g/L; IgG3, 0.19 g/L; IgG4, 0.03 g/L at 6-12 months of age; IgG1, 5.15 g/L; IgG2, 0.87 g/L; IgG3, 0.19 g/L; IgG4, 0.07 g/L at 1-2 years of age; IgG1, 5.26 g/L; IgG2, 1.23 g/L; IgG3, 0.14 g/L; IgG4, 0.11 g/L at 2-3 years of age; IgG1, 6.33 g/L; IgG2, 1.8 g/L; IgG3, 0.2 g/L; IgG4, 0.21 g/L at age 3-4 years; IgG1, 7.05 g/L; IgG2, 1.87 g/L; IgG3, 0.25 g/L; IgG4, 0.29 g/L at 4-6 years of age; IgG1, 6.19 g/L; IgG2, 1.93 g/L; IgG3, 0.2 g/L; IgG4, 0.28 g/L at 6-9 years of age; IgG1, 6.76 g/L; IgG2, 2.29 g/L; IgG3, 0.27 g/L; IgG4, 0.37 g/L at 10-12 years of age; IgG1, 7.45 g/L; IgG2, 2.92 g/L; IgG3, 0.28 g/L; IgG4, 0.38 g/L at 13-16 years of age.
CONCLUSION
To our knowledge, this study is the first to establish RIs for serum IgG subclasses exclusively in Chinese children.
背景
血清 IgG 亚类的参考区间在不同地理区域差异很大。本研究旨在建立中国儿童血清 IgG 亚类的参考区间，这对于解释实验室结果和做出临床决策至关重要。
方法
本研究按照国际临床化学联合会和临床与实验室标准协会提出的 C28-A3 指南进行。共纳入 607 名健康的中国儿童，检测血清 IgG 亚类水平。根据年龄进行分层，通过统计分析确定参考区间。
结果
中国儿童血清 IgG 亚类参考区间的中位数如下：1-6 个月龄时 IgG1 为 2.78 g/L，IgG2 为 0.85 g/L，IgG3 为 0.13 g/L，IgG4 为 0.06 g/L；6-12 个月龄时 IgG1 为 3.64 g/L，IgG2 为 0.73 g/L，IgG3 为 0.19 g/L，IgG4 为 0.03 g/L；1-2 岁时 IgG1 为 5.15 g/L，IgG2 为 0.87 g/L，IgG3 为 0.19 g/L，IgG4 为 0.07 g/L；2-3 岁时 IgG1 为 5.26 g/L，IgG2 为 1.23 g/L，IgG3 为 0.14 g/L，IgG4 为 0.11 g/L；3-4 岁时 IgG1 为 6.33 g/L，IgG2 为 1.8 g/L，IgG3 为 0.2 g/L，IgG4 为 0.21 g/L；4-6 岁时 IgG1 为 7.05 g/L，IgG2 为 1.87 g/L，IgG3 为 0.25 g/L，IgG4 为 0.29 g/L；6-9 岁时 IgG1 为 6.19 g/L，IgG2 为 1.93 g/L，IgG3 为 0.2 g/L，IgG4 为 0.28 g/L；10-12 岁时 IgG1 为 6.76 g/L，IgG2 为 2.29 g/L，IgG3 为 0.27 g/L，IgG4 为 0.37 g/L；13-16 岁时 IgG1 为 7.45 g/L，IgG2 为 2.92 g/L，IgG3 为 0.28 g/L，IgG4 为 0.38 g/L。
结论
据我们所知，本研究首次专门建立了中国儿童血清 IgG 亚类的参考区间。
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