Smt. Kanuri Santhamma Center for Vitreoretinal Diseases, The Retina Institute, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Hyderabad, India.
Standard Chartered Academy for Eye Care Education, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Hyderabad, India.
Retina. 2022 Nov 1;42(11):2128-2133. doi: 10.1097/IAE.0000000000003570.
To describe the comparison of the culture positivity rates of deep vitreous biopsy under air and conventional anterior vitreous biopsy in endogenous endophthalmitis.
A retrospective, consecutive, comparative series including cases of endogenous endophthalmitis from January 2014 to January 2021. They were divided into those where conventional anterior vitreous biopsy was taken and those where a deep biopsy was taken under air (DBA group). The culture positivity rate among the two groups was compared, and factors affecting the same were analyzed by a regression analysis.
There were 140 eyes in the conventional anterior vitreous biopsy group and 44 eyes in the DBA group. Sex, age, duration of symptoms, underlying systemic illness, presenting vision in logMAR, and total number of vitreous interventions were comparable between the two groups. Visual outcome was better in patients undergoing DBA as compared with those who underwent conventional anterior vitreous biopsy , (1.28 ± 1.01 logMAR, 20/380 vs. 1.88 ± 1.33 logMAR, 20/1,500, P = 0.03). No case in the DBA group developed retinal detachment or any complication attributable to the technique. In the conventional anterior vitreous biopsy group, the culture positivity was seen in 43/140 samples (30.71%), and in the DBA group, it was noted in 29/44 samples (65.9%). Taking a DBA was the only factor that was significant both in bivariate (odds ratio 4.36, 95% confidence interval 2.12-8.95, P < 0.0001) and multivariate analysis (odds ratio 4.02, 95% confidence interval 3.1-7.43, P < 0.0001).
Vitreous sampling can be performed from the deep vitreous cavity in endogenous endophthalmitis safely and effectively under air infusion, improving the culture positivity rates.
描述在内源性眼内炎中，空气下深部玻璃体活检与传统前段玻璃体活检的培养阳性率比较。
一项回顾性、连续、对比系列研究，纳入了 2014 年 1 月至 2021 年 1 月期间的内源性眼内炎病例。这些病例分为接受传统前段玻璃体活检的病例和接受空气下深部活检（DBA 组）的病例。比较两组的培养阳性率，并通过回归分析分析影响因素。
传统前段玻璃体活检组有 140 只眼，DBA 组有 44 只眼。两组间的性别、年龄、症状持续时间、基础全身性疾病、logMAR 表现视力和玻璃体干预总次数无差异。与传统前段玻璃体活检相比，DBA 组患者的视力预后更好（1.28±1.01 logMAR，20/380 与 1.88±1.33 logMAR，20/1500，P=0.03）。DBA 组无一例发生视网膜脱离或任何与该技术相关的并发症。在传统前段玻璃体活检组中，43/140 例（30.71%）培养阳性，而在 DBA 组中，29/44 例（65.9%）培养阳性。进行 DBA 是唯一在双变量（比值比 4.36，95%置信区间 2.12-8.95，P<0.0001）和多变量分析（比值比 4.02，95%置信区间 3.1-7.43，P<0.0001）中均有意义的因素。
在空气输注下，可以安全有效地从内源性眼内炎的深部玻璃体腔进行玻璃体取样，提高培养阳性率。
