Vita-Salute San Raffaele University, Milan, Italy.
IRCCS Galeazzi Orthopaedic Institute, Milan, Italy.
Sci Rep. 2022 Jul 20;12(1):12446. doi: 10.1038/s41598-022-15148-z.
Ageing is associated with a progressive decline and remodelling of the immune system. Also, the efficacy of COVID-19 vaccines has been observed to depend on subjects' age. The post-vaccination data about patients aged > 90 years old is scarcely represented in the literature. The antibody titre profiles of elderly vaccinated subjects (age > 90 years old) were evaluated and compared with profiles obtained in a younger population (age 23-69 years old). To the best of our knowledge, this is the first report providing post-vaccination serological data in subjects aged 90 + years old. This study suggests that distinct SARS-CoV-2 viral-specific antibody response profiles vary based on anti-N serostatus, age, and sex in the very elderly adults. The data obtained could impact the organisation of the vaccination campaign (i.e., prioritisation strategies, administration of additional doses) and the factors that facilitate intentions to receive the vaccination among elderly adults (i.e., vaccine effectiveness).
衰老是与免疫系统的逐渐衰退和重塑相关联的。此外，COVID-19 疫苗的功效已被观察到取决于受试者的年龄。关于 90 岁以上患者的疫苗接种后数据在文献中几乎没有体现。评估了老年接种者（年龄>90 岁）的抗体滴度谱，并与年轻人群（年龄 23-69 岁）获得的谱进行了比较。据我们所知，这是首次提供 90 岁以上人群疫苗接种后血清学数据的报告。这项研究表明，非常高龄老年人的 SARS-CoV-2 病毒特异性抗体反应谱因抗-N 血清状态、年龄和性别而异。获得的数据可能会影响疫苗接种运动的组织（即，优先策略、额外剂量的管理）以及促进老年人接种疫苗的因素（即疫苗效力）。
