• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Single-cell sequencing of mouse heart cellular heterogeneity in hypercholesterolemia reveals the mechanism of myocardial damage.

作者信息

Zhang Caihui, Sun Yue, Yang Chen, Wang Qiuyue, Lu Yao

机构信息

Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Ambulatory Surgery Center, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

出版信息

Clin Transl Med. 2022 Jul;12(7):e951. doi: 10.1002/ctm2.951.

DOI:10.1002/ctm2.951
PMID:35859355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9301086/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1003/9301086/66490a68a4f0/CTM2-12-e951-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1003/9301086/cc03e442bd99/CTM2-12-e951-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1003/9301086/bf1727706fb5/CTM2-12-e951-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1003/9301086/1eec6e435215/CTM2-12-e951-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1003/9301086/66490a68a4f0/CTM2-12-e951-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1003/9301086/cc03e442bd99/CTM2-12-e951-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1003/9301086/bf1727706fb5/CTM2-12-e951-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1003/9301086/1eec6e435215/CTM2-12-e951-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1003/9301086/66490a68a4f0/CTM2-12-e951-g003.jpg

相似文献

1
Single-cell sequencing of mouse heart cellular heterogeneity in hypercholesterolemia reveals the mechanism of myocardial damage.高胆固醇血症小鼠心脏细胞异质性的单细胞测序揭示心肌损伤机制。
Clin Transl Med. 2022 Jul;12(7):e951. doi: 10.1002/ctm2.951.
2
Effects of hypercholesterolemia on myocardial ischemia-reperfusion injury in LDL receptor-deficient mice.高胆固醇血症对低密度脂蛋白受体缺陷小鼠心肌缺血再灌注损伤的影响。
Arterioscler Thromb Vasc Biol. 1999 Nov;19(11):2776-81. doi: 10.1161/01.atv.19.11.2776.
3
Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia.冠心病中的高脂血症。II. 176个家族血脂水平的遗传分析及一种新的遗传性疾病——混合型高脂血症的描述
J Clin Invest. 1973 Jul;52(7):1544-68. doi: 10.1172/JCI107332.
4
Coronary heart disease in familiar hypercholesterolemia.
Acta Pathol Jpn. 1975 Mar;25(2):213-23. doi: 10.1111/j.1440-1827.1975.tb00858.x.
5
Hypercholesterolemia and hypertriglyceridemia in children.
Prev Med. 1974 Sep;3(3):390-405. doi: 10.1016/0091-7435(74)90050-4.
6
Cardiac fibrosis and diastolic dysfunction after myocardial infarction in apolipoprotein E knockout mice.载脂蛋白E基因敲除小鼠心肌梗死后的心脏纤维化和舒张功能障碍
Coron Artery Dis. 2009 Nov;20(7):479-82. doi: 10.1097/MCA.0b013e3283319b6c.
7
Hyperlipidemia in coronary heart disease. 3. Evaluation of lipoprotein phenotypes of 156 genetically defined survivors of myocardial infarction.冠心病中的高脂血症。3. 对156名经基因定义的心肌梗死幸存者的脂蛋白表型评估。
J Clin Invest. 1973 Jul;52(7):1569-77. doi: 10.1172/JCI107333.
8
Editorial: Portacaval anastomosis for metabolic disease.
Lancet. 1974 Aug 24;2(7878):444-5.
9
Thromobosis in connection with serum lipidic changes in the rat.大鼠血清脂质变化与血栓形成
Circ Res. 1962 Sep;11:388-99. doi: 10.1161/01.res.11.3.388.
10
[METABOLIC DISORDERS IN ARTERIOSCLEROSIS. I. TOTAL CHOLESTEROL LEVEL AND NUTRITIONAL LIPEMIA].[动脉粥样硬化中的代谢紊乱。I. 总胆固醇水平与营养性血脂异常]
Pol Arch Med Wewn. 1964;34:257-63.

引用本文的文献

1
Multi-Omics and Network-Based Drug Repurposing for Septic Cardiomyopathy.基于多组学和网络的脓毒症性心肌病药物重定位研究
Pharmaceuticals (Basel). 2025 Jan 2;18(1):43. doi: 10.3390/ph18010043.
2
Empowering artificial intelligence in characterizing the human primary pacemaker of the heart at single cell resolution.赋予人工智能以单细胞分辨率描绘人类心脏主起搏点的能力。
Sci Rep. 2024 Jun 18;14(1):14041. doi: 10.1038/s41598-024-63542-6.
3
Interleukin-1β polarization in M1 macrophage mediates myocardial fibrosis in diabetes.白细胞介素-1β在 M1 巨噬细胞中的极化介导糖尿病心肌纤维化。

本文引用的文献

1
The Application of Single-Cell Technologies in Cardiovascular Research.单细胞技术在心血管研究中的应用
Front Cell Dev Biol. 2021 Oct 11;9:751371. doi: 10.3389/fcell.2021.751371. eCollection 2021.
2
The Global Burden of Cardiovascular Diseases and Risks: A Compass for Global Action.心血管疾病及其风险的全球负担：全球行动指南。
J Am Coll Cardiol. 2020 Dec 22;76(25):2980-2981. doi: 10.1016/j.jacc.2020.11.021.
3
Adaptive Immune Responses in Human Atherosclerosis.适应性免疫反应在人类动脉粥样硬化中的作用。
Int Immunopharmacol. 2024 Apr 20;131:111858. doi: 10.1016/j.intimp.2024.111858. Epub 2024 Mar 15.
Int J Mol Sci. 2020 Dec 7;21(23):9322. doi: 10.3390/ijms21239322.
4
Heterogeneity of T Cells in Atherosclerosis Defined by Single-Cell RNA-Sequencing and Cytometry by Time of Flight.单细胞 RNA 测序和飞行时间流式细胞术定义的动脉粥样硬化中的 T 细胞异质性。
Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):549-563. doi: 10.1161/ATVBAHA.120.312137. Epub 2020 Dec 3.
5
Cholesterol induced autophagy via IRE1/JNK pathway promotes autophagic cell death in heart tissue.胆固醇通过 IRE1/JNK 通路诱导自噬促进心脏组织中的自噬性细胞死亡。
Metabolism. 2020 May;106:154205. doi: 10.1016/j.metabol.2020.154205. Epub 2020 Mar 14.
6
Single-Cell Sequencing of Mouse Heart Immune Infiltrate in Pressure Overload-Driven Heart Failure Reveals Extent of Immune Activation.单细胞测序分析压力超负荷诱导的心力衰竭小鼠心脏免疫浸润：揭示免疫激活程度
Circulation. 2019 Dec 17;140(25):2089-2107. doi: 10.1161/CIRCULATIONAHA.119.041694. Epub 2019 Oct 30.
7
Interleukin-17 enhances cardiac ventricular remodeling via activating MAPK pathway in ischemic heart failure.白细胞介素-17 通过激活 MAPK 通路增强缺血性心力衰竭中的心脏心室重构。
J Mol Cell Cardiol. 2018 Sep;122:69-79. doi: 10.1016/j.yjmcc.2018.08.005. Epub 2018 Aug 8.
8
Effect of hypercholesterolaemia on myocardial function, ischaemia-reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning.高胆固醇血症对心肌功能、缺血-再灌注损伤以及预处理、后处理和远程预处理的心脏保护作用的影响。
Br J Pharmacol. 2017 Jun;174(12):1555-1569. doi: 10.1111/bph.13704. Epub 2017 Feb 8.
9
Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice.内皮素受体B是一项针对人类高海拔研究的候选基因，它可提高基因工程杂合子小鼠对缺氧的心脏耐受性。
Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10425-30. doi: 10.1073/pnas.1507486112. Epub 2015 Aug 3.
10
IL-17 contributes to cardiac fibrosis following experimental autoimmune myocarditis by a PKCβ/Erk1/2/NF-κB-dependent signaling pathway.白细胞介素-17 通过蛋白激酶 Cβ/细胞外信号调节激酶 1/2/核因子-κB 依赖性信号通路促进实验性自身免疫性心肌炎后的心肌纤维化。
Int Immunol. 2012 Oct;24(10):605-12. doi: 10.1093/intimm/dxs056. Epub 2012 Apr 24.