Chen Yinan, Liu Yang, Gao Xiang
Fuwai Hospital, Chinese Academy of Medical Sciences, Shenzhen, China.
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Front Cell Dev Biol. 2021 Oct 11;9:751371. doi: 10.3389/fcell.2021.751371. eCollection 2021.
Cardiovascular diseases (CVDs) are the leading cause of deaths in the world. The intricacies of the cellular composition and tissue microenvironment in heart and vasculature complicate the dissection of molecular mechanisms of CVDs. Over the past decade, the rapid development of single-cell omics technologies generated vast quantities of information at various biological levels, which have shed light on the cellular and molecular dynamics in cardiovascular development, homeostasis and diseases. Here, we summarize the latest single-cell omics techniques, and show how they have facilitated our understanding of cardiovascular biology. We also briefly discuss the clinical value and future outlook of single-cell applications in the field.
心血管疾病（CVDs）是全球主要死因。心脏和血管中细胞组成及组织微环境的复杂性使得剖析心血管疾病的分子机制变得困难。在过去十年中，单细胞组学技术的迅速发展在多个生物学层面产生了大量信息，这些信息揭示了心血管发育、稳态和疾病中的细胞及分子动态。在此，我们总结了最新的单细胞组学技术，并展示了它们如何促进我们对心血管生物学的理解。我们还简要讨论了该领域单细胞应用的临床价值和未来前景。
