葡聚糖对BALB/c小鼠利什曼原虫主要感染的影响。
Effect of glucan on Leishmania major infection in BALB/c mice.
作者信息
Al Tuwaijri A S, Mahmoud A A, Al Mofleh I A, Al Khuwaitir S A
出版信息
J Med Microbiol. 1987 Jun;23(4):363-5. doi: 10.1099/00222615-23-4-363.
The effect of glucan on Leishmania major infection was studied in BALB/c mice, which are highly susceptible to leishmania infection. Glucan (0.45 mg), or isovolumetric dextrose, was administered intraperitoneally 7, 5, 3 and 1 day before infection with L. major promastigotes. At 3, 5, 6, 8 and 10 weeks after infection, animals were killed; the liver and spleen of each animal were weighed and the parasite burden was calculated. A significant (p less than 0.01) reduction in amastigote proliferation in liver and spleen of animals pretreated with glucan was demonstrated 4, 6 and 8 weeks after infection.
在对利什曼原虫感染高度敏感的BALB/c小鼠中研究了葡聚糖对硕大利什曼原虫感染的影响。在感染硕大利什曼原虫前鞭毛体7天、5天、3天和1天，腹腔注射葡聚糖（0.45毫克）或等体积的葡萄糖。在感染后3周、5周、6周、8周和10周处死动物；称量每只动物的肝脏和脾脏重量，并计算寄生虫负荷。结果显示，在感染后4周、6周和8周，用葡聚糖预处理的动物肝脏和脾脏中的无鞭毛体增殖显著减少（p<0.01）。
Zotero 插件