Vetvicka V, Fernandez-Botran R
University of Louisville, Department of Pathology, 511 S. Floyd, Louisville, KY 40202, USA.
Helminthologia. 2018 Jul 28;55(3):177-184. doi: 10.2478/helm-2018-0021. eCollection 2018 Sep.
Immunosuppression caused by parasitic infections represents the foremost way by which the parasites overcome or escape the host's immune response. Glucan is a well-established natural immunomodulator with the ability to significantly improve immune system, from innate immunity to both branches of specific immunity. Our review is focused on the possible role of glucan's action in antiparasite therapies and vaccine strategies. We concluded that the established action of glucan opens a new window in treatment and protection against parasitic infections.
寄生虫感染引起的免疫抑制是寄生虫克服或逃避宿主免疫反应的首要方式。葡聚糖是一种公认的天然免疫调节剂,能够显著改善免疫系统,从先天免疫到特异性免疫的两个分支。我们的综述重点关注葡聚糖在抗寄生虫治疗和疫苗策略中的可能作用。我们得出结论,葡聚糖已确定的作用为治疗和预防寄生虫感染打开了一扇新窗口。