Subhan Muhammad, Saji Parel Nisha, Krishna Parimi Vamsi, Gupta Anuradha, Uthayaseelan Kamsika, Uthayaseelan Kivonika, Kadari Monika
Internal Medicine, Jinnah Hospital, Allama Iqbal Medical College, Lahore, PAK.
Family Medicine, Tbilisi State Medical University, Tbilisi, GEO.
Cureus. 2022 Jun 16;14(6):e26009. doi: 10.7759/cureus.26009. eCollection 2022 Jun.
Pancreatic cancer (PC) is the primary cause of cancer death in the United States and Europe. Despite remarkable advances in the molecular understanding of PC and advances in new therapeutic approaches, PC remains a disease with a poor prognosis. Although evidence indicates that long-term smoking is a major cause of PC, the molecular pathways behind smoking-induced PC pathogenesis are not fully understood. Smoking cessation can significantly reduce the occurrence of PC. This review explores the processes underpinning the influence of smoking-related chemicals on fibrosis and inflammation and provides insight into the etiology of PC. In the future, a thorough exploration of the effects of smoking chemicals on the activity of pancreatic stem cells and then on the essential mediators of the association with cancer cells would likely yield new diagnostic targets.
胰腺癌（PC）是美国和欧洲癌症死亡的主要原因。尽管在对PC的分子理解以及新治疗方法方面取得了显著进展，但PC仍然是一种预后较差的疾病。虽然有证据表明长期吸烟是PC的主要原因，但吸烟诱导的PC发病机制背后的分子途径尚未完全了解。戒烟可以显著降低PC的发生率。本综述探讨了吸烟相关化学物质对纤维化和炎症影响的潜在过程，并深入了解了PC的病因。未来，深入探索吸烟化学物质对胰腺干细胞活性的影响，进而对与癌细胞关联的关键介质的影响，可能会产生新的诊断靶点。
